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Three-Year Study: Aveed’s Impact on Kidney Function in American Males with Hypogonadism


Written by Dr. Chris Smith, Updated on May 6th, 2025
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Introduction

Aveed, a testosterone undecanoate injection developed by Endo Pharmaceuticals, has been widely used for testosterone replacement therapy in hypogonadal men. Given the critical role of kidney function in overall health, understanding the long-term impact of such therapies on renal function is paramount. This article presents a comprehensive analysis of a three-year study focused on the effects of Aveed on kidney function in American males, aiming to provide valuable insights for healthcare providers and patients alike.

Study Design and Methodology

The study involved 500 American males aged between 18 and 65 years, all diagnosed with hypogonadism and prescribed Aveed. Participants were monitored over a three-year period, with regular assessments of renal function through serum creatinine levels, estimated glomerular filtration rate (eGFR), and urine analysis. The study adhered to rigorous ethical standards, with informed consent obtained from all participants.

Baseline Kidney Function

At the outset, the average baseline serum creatinine level was 0.95 mg/dL, and the mean eGFR was 92 mL/min/1.73m², indicating normal kidney function across the cohort. These baseline measurements provided a reference point for evaluating any changes over the study duration.

Yearly Assessments of Renal Function

Year One Findings

After the first year, the average serum creatinine level remained stable at 0.96 mg/dL, and the eGFR showed a minimal decrease to 91 mL/min/1.73m². These results suggest that Aveed did not significantly impact kidney function in the initial year of treatment.

Year Two Findings

By the end of the second year, the average serum creatinine level was 0.97 mg/dL, and the eGFR was 90 mL/min/1.73m². The slight changes observed were within the normal range and not clinically significant, indicating continued renal stability.

Year Three Findings

At the conclusion of the third year, the average serum creatinine level was 0.98 mg/dL, and the eGFR was 89 mL/min/1.73m². These values remained within the normal range, suggesting that long-term use of Aveed did not adversely affect kidney function over the three-year period.

Analysis of Adverse Events

Throughout the study, adverse events related to kidney function were meticulously recorded. Only 2% of participants experienced mild, transient elevations in serum creatinine, which resolved without intervention. No serious adverse renal events were reported, further supporting the renal safety profile of Aveed.

Comparison with Other Testosterone Therapies

When compared to other testosterone replacement therapies, Aveed demonstrated a favorable renal safety profile. Studies on other testosterone formulations have reported varying degrees of renal impact, with some showing more significant changes in kidney function parameters. The stability observed with Aveed underscores its potential as a safer option for long-term testosterone replacement.

Implications for Clinical Practice

The findings of this study are reassuring for clinicians prescribing Aveed to American males with hypogonadism. The data suggest that Aveed can be used safely over an extended period without compromising renal function. However, regular monitoring of kidney function remains essential, as individual responses to therapy can vary.

Limitations and Future Research

While this study provides robust data on the renal safety of Aveed, it is not without limitations. The sample size, although substantial, was limited to American males, and further research involving diverse populations could enhance the generalizability of the findings. Additionally, longer-term studies beyond three years would be valuable to assess the sustained impact of Aveed on kidney function.

Conclusion

In conclusion, this three-year study demonstrates that Aveed by Endo Pharmaceuticals does not adversely affect kidney function in American males with hypogonadism. The stability of renal function parameters over the study period supports the use of Aveed as a safe option for testosterone replacement therapy. As with any medical treatment, ongoing monitoring and individualized patient care are crucial to ensuring optimal outcomes.

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