Reading Time: 2 minutesIntroduction Late-onset hypogonadism (LOH), characterized by a gradual decline in serum testosterone levels in aging men, affects up to 30% of American males over 60, according to data from the National Health and Nutrition Examination Survey (NHANES). This endocrine perturbation extends beyond reproductive health, influencing cardiometabolic systems, including the liver—one of the body's primary metabolic hubs. Emerging research highlights a bidirectional relationship between LOH and hepatic dysfunction, particularly non-alcoholic fatty liver disease (NAFLD), which afflicts approximately 25% of U.S. adults. This article elucidates the pathophysiological mechanisms, epidemiological correlations, and clinical ramifications of LOH on liver function and disease risk, tailored … Continue reading →