Reading Time: < 1 minuteIntroduction Erectile dysfunction (ED) remains a pervasive comorbidity among American males afflicted with infectious diseases, including human immunodeficiency virus (HIV), hepatitis C virus (HCV), and sexually transmitted infections (STIs) such as chlamydia and gonorrhea. Epidemiological data from the Centers for Disease Control and Prevention (CDC) indicate that over 1.2 million U.S. adults live with HIV, with ED prevalence exceeding 70% in this cohort due to vasculopathy, neuropathy, antiretroviral toxicities, and psychological distress. Phosphodiesterase type 5 inhibitors (PDE5i), exemplified by avanafil (Stendra®), offer rapid-onset, selective inhibition of PDE5, facilitating corpus cavernosum smooth muscle relaxation and enhanced penile blood flow. This longitudinal … Continue reading →