B12 Injection Therapy as Part of Hormone Replacement Therapy – Video

Written by Dr. Chris Smith, Updated on February 26th, 2024
Reading Time: 7 minutes

B12 Guide – How to Inject Vitamin B12

Vitamin B12 is one of the many essential nutrients that the body needs to operate at its fullest capacity.

Vitamin B12 is responsible for facilitating a process related to the body's most basic form of energy—ATP. Without ATP, human life would not be possible. B12 activates the mitochondria in our cells, which then produce ATP.

Vitamin B12 Deficiency is one of the more common forms of Vitamin Deficiency. It is not only caused by malnutrition, but also by digestive issues which prevent the proper absorption of Vitamin B12.

This can occur to individuals of all ages, but it is common for the human body to lose its ability to absorb Vitamin B12 as men and women grow older.

For folks with Vitamin B12 Deficiency, the symptoms can be widespread and significant. Symptoms of B12 Deficiency include fatigue, poor sleep, weight gain, depression, lack of focus, impaired immune health, and more.

For these people, Vitamin B12 injections can provide incredible wellness benefits. Vitamin B12 Injections can even lead to hair growth!

Vitamin B12 Compatible with Hormone Replacement Therapy and Most Weight Loss Programs

Many patients with Vitamin B12 Deficiency are overweight, mainly resulting from their body's impeded metabolism.

B12 Injections can be helpful for weight loss because they encourage increased metabolism, which boosts Basal Metabolic Rate, and because increased energy levels make it easier to work out or otherwise stay active.

Though B12 Injections can provide excellent health benefits on their own, combining them with other Wellness Treatments will give even more remarkable results.

HGH Therapy and Bio-Identical Testosterone Therapy also uplift energy and increase fat-burning power, and combining their effects with B12 only amplifies results. B12 Injections are also compatible with the HCG Diet and effective weight loss supplements, including Methionine, Choline, and Inositol.

Why Choose B12 Injections over Vitamin B12 Supplements?

Oral B12 supplements may be beneficial for some patients, but many people have issues with the proper absorption of B12 via the digestive tract.

This malfunction tends to become more problematic and severe in correlation with age. That means that it is possible that dietary and oral B12 will not meet your physiological need for the vitamin.

Vitamin B12 injections deliver the vitamin directly into the bloodstream, bypassing the digestive system entirely.

Then B12 can circulate through the blood and perform its vital functions. The most effective form of B12 Supplementation by far is the B12 Shot. The two main types of B12 Injection are Methylcobalamin and Cyanocobalamin—Methylated B12 Injections are by far the most effective.

Methylcobalamin vs. Cyanocobalamin

Both Cyanocobalamin and Methylcobalamin are widely used in B12 Supplements, but you should always opt for Methylcobalamin. Supplements that use Cyanocobalamin are less expensive, but they also don't work as well.

Methylcobalamin stands for Methylated B12. This is the way that the body is used to experiencing Vitamin B12 in nature, and the body can immediately put Methylcobalamin to use in Mitochondrial Cells.

Cyanocobalamin is a synthesized form of Vitamin B12 that is combined with a Cyanide molecule (though the dosage is much lower than the body's threshold for Cyanide poisoning).

Though Cyanocobalamin isn't dangerous, it just isn't as effective. The most significant benefit of Methylcobalamin over Cyanocobalamin is that Methylcobalamin stays active in the body longer, allowing it to provide more significant gains.

Also, there are some advantages that Methylcobalamin can offer that Cyanocobalamin cannot, including improved focus via enhanced visual accommodation and improved Circadian Rhythm.

How Can I Get Vitamin B12? How Do I Ensure the Effectiveness of Treatment?

Though Oral B12 Supplements are available over-the-counter, B12 Injections are only available with a doctor's prescription.

B12 Injections are very safe. It's practically impossible to overdose on Vitamin B12 because B12 belongs to the class of water-soluble vitamins that pass through the urine rather than being absorbed into body fat.

Because B12 is water-soluble, the Vitamin must act quickly, so it is utilized more thoroughly, which is why Methylcobalamin is so superior to Cyanocobalamin.

Most Vitamin B12 Injections are designed for weekly administration. A good rule of thumb is one 5,000 microgram injection per week, though some patients may require a dose every five days.

Are B12 Injections Safe?

As we mentioned earlier, Vitamin B12 Shots provide significant benefits at minimal risk to the patient.

The most commonly reported side-effect of B12 Injection is irritation at the injection site, but this is minor and more associated with the use of a needle than with the content of the injection itself.

Vitamin B12 is often administered at a clinic or pharmacy by a professional, but it is perfectly acceptable to self-administer the injection. Patients with significantly impaired kidney function should not take high doses of Vitamin B12.

How to Self-Administer a B12 Injection

Most B12 Injections are delivered via both Intramuscular and Subcutaneous Injections. Intramuscular (IM) Shots are given into muscle tissue, whereas Subcutaneous Shots (SubQ) are delivered into the body fat directly underneath the dermis.

Aside from the location, the procedure for Self-Administered Injection is pretty much the same. This information is intended merely as a guide, and you should follow your physician's instructions and advice regarding injection protocol.

Step One – Clean Your Work Space and Your Hands

Before getting started, clean your hands thoroughly with antibacterial soap and disinfect the area where you will be performing the injection.

If self-administering the injection, you can use your bare hands, but if you are helping someone else with an injection, use gloves.

Step Two – Gather Injection Supplies

After your hands are clean, collect the tools you will be using and arrange them in your disinfected space.

This includes your needle, cotton, bandages, syringe, rubbing alcohol, Sharps container, and Vitamin B12 vial.

For Intramuscular Injection, the ideal needle will be 1-1.5 inches long and 22-25 gauge, the smaller the measure, the less discomfort associated with the injection.

Subcutaneous Injections use a shorter and smaller-gauge needle because the medication isn't being injected as deeply underneath the skin.

Step Three – Secure the Needle to the Syringe

With your clean hands, take the needle and attach it directly to the syringe, twisting it into position. It's essential not to touch the tip of the needle. If you do touch the tip of the needle, discard it and start again.

Step Four – Draw in the Medication

Take the B12 vial and disinfect it with a swab of alcohol. Take the syringe and draw back the plunger until the amount of air in the syringe is equal to your intended dosage. Take the needle and plunge it directly through the stopper into the vial at a right angle.

After the needle is in the vial, press down on the plunger and fill the bottle with the air from the syringe. This pressurizes the sealed jar, making it easier to withdraw the medication.

Draw back the plunger until the correct dose has been drawn. Pull the needle and syringe out from the vial carefully and set the syringe aside, careful not to touch the needle.

Step Five – Prepare Your Skin for the Injection

Before administering the dose, choose an appropriate site on the body. Depending on the type of injection, this location can and will vary:

Intramuscular Injection – Intramuscular Injections will be delivered straight into muscle tissue. The most common site for injection is into the deltoids, but other large muscles such as the glutes or thighs can also be used as well.

Subcutaneous Injections – Subcutaneous Injection is administered at an angle into the tissues just below the skin. Areas such as the fat of the arm, into the fat of the stomach, or the side are also prime locations.

Take the cotton ball and coat it with rubbing alcohol. Rub the alcohol into the skin to disinfect the area and minimize the risk of irritation and infection.

Step Six – Deliver the Medication

Take the needle and tilt it with the tip of the needle facing straight up. Tap the side of the syringe to free any bubbles that might be trapped, then depress the plunger slightly to evacuate the air, which is now stuck at the tip of the needle.

From here, depending on the type of injection, the process of administering the shot will vary slightly:

For Intramuscular Injection, the needle should be plunged directly into the muscle tissue at a right angle using a steady yet rapid motion.

For Subcutaneous Injection, the injection will be performed in the same manner, but at a 45-degree angle. This is because the needle is shorter and needs to reach subcutaneous tissue without plunging too deep.

After the needle is injected, draw back the plunger slightly to make sure that you didn't puncture a blood vessel.

If you see blood when you draw back the plunger, start the process over with a new needle. If you feel an intense burning or tingling sensation, then you should also launch the process over, because you may have knicked a vein.

If all is well, press down the plunger steadily, dispersing the medication into the chosen tissue. Once complete, draw the needle out and discard the syringe and needle into a sharps container or other thick-walled suitable container, such as a laundry detergent bottle.

Step Seven – Post-Injection Clean-Up

After the injection is complete, there may be slight bleeding. Use a cotton ball to sop up any potential blood and cover with a bandage if necessary.


Vitamin B12 (injection)


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