What are the Benefits of Sermorelin Acetate Injections versus HGH Injections?

Written by Dr. Chris Smith, Updated on December 25th, 2023
Reading Time: 7 minutes

Men and Women Can Benefit from SErmorelinAdult Growth Hormone Deficiency

There are two main categories of hormone treatment available to provide relief from HGH Deficiency:

1. Injectable Bio-Identical HGH therapy

2. GH-RH (Growth Hormone-Releasing Hormone) Therapy with Sermorelin Acetate injections.

HGH Products

Many HGH brands are utilized to provide Growth Hormone Therapy to choose from, including 1. Genotropin, 2. Saizen, 3. Tev Tropin, 4. Nutropin, 5. Humatrope, and 6. Omnitrope.

Sermorelin Products

GH-RH (Growth Hormone-Releasing Hormone) therapy is administered using two derivative Recombinant Hormone Treatments — Sermorelin Therapy and Tesamorelin Therapy.

Because these two medical treatments are virtually interchangeable, for the remainder of the article, we will refer solely to Sermorelin Acetate.

Sermorelin does not come in a name brand. It is usually compounded at American Pharmacies.

How Does Human Growth Hormone Therapy Work?

Bio-Identical Growth Hormone Therapy works by directly supplementing the waning production of natural HGH by your own body.

Post-Puberty Human Growth Hormone Production peaks around the age range of our teens to the early 20s, and starts to dwindle slowly over time.

By one's 30s HGH decline becomes apparent and people begin to start noticing some significant changes creeping up. Over many years or decades, HGH levels in the blood drop to a point at which the natural hormone levels no longer meet the needs of the body.

You might remember the first time in your 30s when you realized things don't seem to be healing as fast as they used to.

With Physician-Monitored HGH Therapy, our hormone specialist doctor will prescribe you a dose of Injectable HGH designed to get your IGF-1 Levels back to what would be considered normal for a man or woman in their late twenties and earlyish 30s.

In doing so, it is possible to enhance cellular metabolism and provide all of the significant benefits of HGH replenishment and balance. And there are many benefits to Growth Hormone therapy that we will discuss in this article and others on our HGH and Sermorelin research site.

How Does Sermorelin Acetate Therapy Work?

The goal of Injectable Sermorelin Acetate is the same as Bio-Identical Human Growth Hormone — To boost HGH Levels in the bloodstream to levels associated with early adulthood.

It is the boost of HGH levels that stimulate the liver to increase its release of Insulin-like Growth Factor One (IGF-1). Sermorelin Acetate shots do this by a different mechanism, however.

What is Sermorelin?

Sermorelin is the functional and bio-active (meaning the working part) analog (shortened version) of another hormone known as Growth Hormone-Releasing Hormone or GH-RH.

As you may be able to figure out just by looking at the name, you can likely figure out what GH-RH does. It is an HGH secretagogue that stimulates the body to produce its own Human Growth Hormone and therefore, by proxy, increases IGF-1.

How Does the Body Make Growth Hormone?

To more fully understand how Sermorelin works, let's take a moment to reflect on the mechanisms which promote the release of HGH from the pituitary. It all starts at the Hypothalamus, which is considered one of the command and control centers at the back seat of the brain.

When the Hypothalamus receives stimuli from the body which indicates that HGH needs to be produced, it secretes GH-RH in direct response. This GH-RH flows from the Hypothalamus to the Pituitary Gland via a route known as the Hypophyseal Portal System, a series of blood vessels that allow hormones to pass between these two regions/organs of the brain.

Sermorelin HGH Alternative

HGH is released by cells known as Somatotrophs, which are located in the Anterior Pituitary (front part of the pituitary).

When GH-RH activates these Somatotroph Cells, they respond directly by releasing Growth Hormone, which then flows through the bloodstream, either acting directly upon cells or indirectly via IGF-1 and other Growth Factors after being metabolized by the liver.

Sermorelin Acetate Imitates the Function of GH-RH Growth Hormone-Releasing Hormone

Sermorelin works by essentially playing the role of GH-RH, facilitating the production of Human Growth Hormone release into the bloodstream.

Sermorelin has the same impact on the body as GH-RH, even though it is made up of a slightly different biological structure.

What is Growth Hormone Releasing Hormone?

GH-RH is a long chain polypeptide hormone, made up of 41-44 individual amino acids.

Researchers discovered that only the first 29 amino acids comprise the functional and therefore working component of GH-RH, and by synthesizing a chain of the first 29 amino acids of this hormone, it is possible to influence HGH Production in the exact same manner as GH-RH. The 29 amino acid version is called Sermorelin.

Some Patients Will Not Respond Effectively to Sermorelin Acetate

It is important to note here that there are two forms of HGH Deficiency (which is a form of Hypopituitarism) — Primary HGH Deficiency and Secondary HGH Deficiency:

Primary HGH Deficiency refers to any medical condition which directly suppresses the functional ability of the Pituitary to produce Human Growth Hormone. Most often, this is the result of tumors, damage to the pituitary, surgery, genetic or congenital disabilities.

Secondary HGH Deficiency refers to any medical condition that causes the Pituitary Gland not to receive the proper signal to produce Human Growth Hormone. There are many causes of Secondary HGH Deficiency, and many factors that can exacerbate the condition, including:

  • Conditions that impact the function of the Hypothalamus or Thyroid Gland
  • Natural Aging

Issues Which Can Exacerbate Secondary HGH Deficiency

  • Sedentary Lifestyle
  • Obesity
  • Drinking
  • Smoking
  • Poor Sleep
  • Anxiety

Physician Prescribed Sermorelin Acetate

Sermorelin Acetate Treats Secondary HGH Deficiency

Sermorelin GH-RH Therapy is specifically designed to resolve Secondary Hypopituitarism and HGH Deficiency.

Patients with Primary HGH Deficiency will not produce sufficient Human Growth Hormone to meet the needs of the body even when GH-RH levels are normal, because no level of GH-RH will effectively promote an unhealthy pituitary. Most of us have healthy pituitary glands that just need stimulation and Sermorelin serves this purpose well.

Treating Secondary HGH Deficiency with Sermorelin

On the other hand, Sermorelin Acetate is just as effective at treating Human Growth Hormone Deficiency in patients suffering from Secondary Hypopituitarism, because patients with Secondary Hypopituitarism have a perfectly healthy and functional Pituitary Gland, they don't receive enough GH-RH Signaling.

In fact, Age-Related HGH Deficiency is the most common form of Adult-Onset Human Growth Hormone Deficiency, and it is caused explicitly by declining GH-RH Release by the Hypothalamus.

That means that both Sermorelin and HGH can effectively treat this most common form of Adult Growth Hormone Deficiency. Our physicians tend to like Sermorelin over HGH because it works better with the body and is more affordable.

Why is Sermorelin Acetate Superior to Bio-Identical HGH for Some Patients?

In fact, there is substantial clinical evidence that for patients with Secondary HGH Deficiency, Sermorelin Acetate can be the better choice for the treatment of Growth Hormone Deficiency. There are a few reasons for this, and all of them are important:

Sermorelin Acetate Preserves a More Natural Hormone Balance

Sermorelin is less prone to an issue known as Tachyphylaxis than with Human Growth Hormone Injections. Tachyphylaxis is a condition in which the brain recognizes abnormal patterns of hormones or medications within the body and adjusts its sensitivity to such hormones or medicines in response.

In some cases, the body may develop a slight resistance to Growth Hormone Injections over time. Sermorelin Acetate Injections, on the other hand, increases HGH within the body on its own schedule, and this reduces the risk of Tachyphylaxis from occurring.

Sermorelin Acetate is Cheaper than Bio-Identical Human Growth Hormone

This primarily benefits the wallet of the patient. For many patients, Sermorelin and HGH are not available via health insurance, so the cost of the treatment is significant.

Sermorelin Acetate is cheaper than Human Growth Hormone and provides similar benefits, even potentially superior benefits. This drives many to turn to Sermorelin rather than Bio-Identical HGH.

Sermorelin Acetate Has a Lower Incidence of Side-Effects

Because Sermorelin acts higher up in the hormone cascade than Growth Hormone (GH), the body has more mechanisms to control the function of Sermorelin and therefore can limit the production of Human Growth Hormone if the hypothalamus receives sufficient signal.

When Human Growth Hormone is injected into the body, it is absorbed and put to use immediately, and there are few mechanisms in place to limit the activity of HGH in the bloodstream once it is there other than an immune response which can cause flu-like symptoms with HGH.

That's not to say that Human Growth Hormone Therapy isn't safe when used appropriately, it means merely that Sermorelin reduces the risk of side effects associated with accidental overdose.

Sermorelin Acetate Can Be Prescribed Off-Label

Today, bio-identical Human Growth Hormone therapy is very tightly regulated, mostly because of its longtime use and abuse as a performance-enhancing drug.

Because of this, the FDA decided to restrict the purposes for which HGH could be used significantly. HGH is only legally available for patients suffering from Childhood or Adult-Onset HGH Deficiency, Idiopathic Short Stature in Children, and the treatment of AIDS-Related Cachexia.

Also, the adult patient must fall within a particular range to be legally approved for treatment. Our HGH clinic only provides treatment for patients who are over the age of 30.

With Sermorelin Acetate, the physician has more freedom to prescribe the treatment to patients that he or she feels would benefit.

That is not to say injectable Sermorelin can be prescribed explicitly for reasons related to performance enhancement, but, if a doctor thinks that the patient can benefit from Sermorelin Therapy, they are free to prescribe the treatment with fewer restrictions.

Talk to a Hormone Specialist to Learn More!

As you can see, Human Growth Hormone and Sermorelin Acetate perform very similar functions within the body, but they do have some subtle differences. Not every patient with HGH Deficiency will respond to Sermorelin Acetate, but most will react to Bio-Identical Growth Hormone.

On the other hand, for patients that respond to Sermorelin Acetate, the medication provides many advantages over Human Growth Hormone that make it an excellent choice for treatment.

Are You a Candidate for Growth Hormone or Sermorelin Therapy?

If you feel that you may be suffering from Growth Hormone Deficiency, and want to learn more about your options, there are qualified medical professionals all across the country that can help you get the treatment that you need, give our specialists at the Conscious Evolution Institute of Hormone Replacement Therapy a call.

The Conscious Evolution Institute is a licensed and board-certified medical clinic that specializes in Hormone Replacement products and services.

We can answer any questions that you may have as well as set you up with an appointment with a local affiliate physician in your area who is qualified to perform the preliminary blood testing that will provide a clear image of your Hormone levels.

Our physicians can examine your blood work and offer potential treatment options available to you as a patient.

Sermorelin, Testosterone, and other HRT therapeutics are available as well working in combination, and all of our programs are co-created with you to serve your goals and needs. Fill out the contact form and contact us today.


The Safety and Efficacy of Growth Hormone Secretagogues


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