Effective, Safe Results with Oral Testosterone in Men With Low-T
Testosterone Replacement Therapy (TRT) has proven to be incredibly effective for aging men in their quest to turn the clock back. Hypogonadism (aka Low testosterone levels or “Low-T”) plays a significant role in the appearance of symptoms of aging such as:
• Chronic fatigue.
• A weakened immune system that sets the stage for the onset of many diseases, including severe afflictions.
• A loss of strength and muscle size.
• Depression.
• Trouble concentrating.
• Irritability.
• Insomnia.
• Prolonged muscle soreness after a workout due to a diminished recovery capacity.
• Erectile dysfunction (ED).
• A collapsing libido.
• And more, many more symptoms of vanishing manhood.
Faced with these developments, it is easy to see why many men are exploring testosterone treatments to determine if it is right for them.
A hesitation about injections
Intramuscular injection (IM) is the standard for administering testosterone since it is easily absorbed with this method. But there are also other ways of putting the “manly hormone” to work: testosterone patches, creams, and pellets, all of which have proven effective.
But none of these methods are as convenient as swallowing a pill. Until recently, oral testosterone administration was discouraged since there was an increased risk of liver toxicity.
However, recent experiments and alterations resulted in a new preparation method that has shown promise in creating safe and effective testosterone pills.
Here is a brief review of recent studies.
MIAMI -- Oral testosterone replacement therapy (TRT) appeared safe and effective in men with low testosterone, according to a recent study. Among nine studies that measured changes in serum total testosterone, men with testosterone deficiency who took an oral agent -- predominantly testosterone undecanoate -- saw a significant increase in total testosterone, with a mean change of 1.25 ng/mL (95% CI 0.22-2.29), according to Jake A. Miller, MD, of the University of California Irvine.
And in eight studies that uncovered adverse side effects, there was no significant change in risk in patients taking oral testosterone versus placebo, with a risk ratio of -0.03 (95% CI -0.08 to 0.03), he said at the Sexual Medicine Society of North America (SMSNA) annual meeting.
Miller stated that testosterone undecanoate was "not necessarily something that's new. I just think that, unfortunately, it [oral testosterone in general] got stigmatized very early on, as far as its use, and now we're starting to see that with the new formulation, we're challenging some of those concerns."Earlier forms of oral testosterone, like methyltestosterone, increased the risk of high blood pressure, elevated liver enzymes, and prostate swelling due to its swift metabolism. Consequently, "multiple guidelines...essentially made a hard line to say 'Do not use oral testosterone for these patients, just use injection, just use gel, just use intranasal,'" since these formulations are absorbed less rapidly, Miller said.
Three forms of oral undecanoate testosterone are currently approved by Food and Drug Administration (FDA) (Tlando, Kyzatrex, and Jatenzo). These could offer an alternative for patients who can't use other ways of taking testosterone.
The nine studies that compared oral testosterone to placebo had 606 patients and spanned from 1989-2019, while the eight studies of adverse effects had 849 patients. Most of the patients were adult males with diagnosed Low-T, said Miller. The analysis excluded women and transgender patients who were taking oral testosterone since these patients usually take several forms of testosterone.
Two studies reported heightened incidences of adverse effects for both placebo and control groups, while five reported very low incidences of adverse effects for both groups. Miller said that was a result of different criteria for what was considered an adverse effect.
He said that "despite having some of this new data available, when they [guidelines] discuss oral testosterone, it's clear based on the resources that they are only reviewing the data from the 1970s population, and excluding the more recent stuff. What we're hoping to achieve with our paper is to say, 'Maybe we should start to re-evaluate now the new work [data] coming out.'"
Another study of oral testosterone undecanoate (TU, Jatenzo) found it effective for men with low testosterone levels, with no evidence of liver damage. The conclusions were presented at ENDO 2021, the Endocrine Society’s annual meeting.
TRT is currently available in various administration methods, such as pellets, gels, and intramuscular injections. “For many men with low testosterone levels, an oral option is preferred to avoid issues associated with other modes of administration, such as injection site pain or transference to partners and children,” stated lead researcher Ronald S. Swerdloff, M.D. of the Lundquist Research Institute in Torrance, California. “Before TU was approved, the only orally approved TST in the United States was methyl-testosterone, which was known to be associated with significant chemical-driven liver damage.”
The (FDA) approved TU in March 2019, and the medication was made commercially available in February 2020.
Swerdloff presided over a safety and efficacy analysis of two years of TU oral pill administration in men with Low-T. The study was divided into two parts. The first part included men ages 18 to 75 with Low-T who were monitored for 12 months. The second study consisted of 86 men and lasted for another year.
TU maintained total testosterone levels in the standard range for two years, with safety databases similar to other testosterone products. There was no evidence of liver toxicity. There were minor but statistically significant increases in prostate-specific antigen (PSA), a protein manufactured by the prostate, and hematocrit (HCT), which measures red blood cell levels.
Swerdloff noted these increases are found with other forms of testosterone therapy, regardless of how it is taken. The drug had insignificant effects on LDL “bad” cholesterol, decreasing HDL “good” cholesterol, as usual with other TRT treatments.
“Our study finds TU is an effective oral therapy for men with low testosterone levels and has a safety profile consistent with other approved testosterone products, without the drawbacks of non-oral modes of administration,” Swerdloff said.
Our clinic will discuss all the various options available to you for TRT. We will cover the pros and cons of each method in detail, and our recommendations will be given based on our decades of experience in hormone replacement.
Contact us for a FREE, no-obligation discussion about the remarkable benefits of Testosterone Replacement Therapy (TRT).
References
https://www.medpagetoday.com/meetingcoverage/smsna/101493
Contact Us For A Fast And Professional Response

- Bodybuilding, HGH, and Staying at the Top of Your Game - March 1st, 2023
- Wheat Germ Can Be a Part of Your Health Plan - December 21st, 2022
- Boost testosterone with a few minor changes - December 6th, 2022
- Finally! An easy way to boost metabolism: The Soleus Pushup - November 30th, 2022
- Sermorelin or Growth Hormone? - November 16th, 2022
- The Benefits of Semax - November 9th, 2022
- Vitamins That Revitalize and Restore Healthy Hair - November 7th, 2022
- Causes of Sex Drive Differences in Couples - October 27th, 2022
- Outside Factors Influence Testosterone Treatment - October 12th, 2022
- Growth Hormone acts on the brain to conserve energy during weight loss - October 5th, 2022
- Male Designer and Model Discusses Pros and Cons of Early Testosterone Therapy - October 3rd, 2022
- Another Way Our Clinic Can Save You - September 28th, 2022
- Recent Study Concludes: Testosterone Promotes Cuddling as well as Aggression - September 28th, 2022
- Can You Believe That Testosterone Actually Promotes Cuddling? - September 16th, 2022
- Hormone Imbalance May Impact Weight More Than Caloric Intake - August 2nd, 2022
- What Do You Mean, “Board Certified Physicians”? - June 23rd, 2022
- Correlation Between Low Testosterone and Unemployment - June 14th, 2022
- Types and Causes of Hypogonadism - January 17th, 2022
- Sleep Deprivation and Disruption Contribute to Erectile Dysfunction - December 12th, 2021
- Zomacton Prescriptions for Human Growth Hormone Deficiency - October 30th, 2021
- Getting to the Root of Erectile Dysfunction – Six Causes of ED - October 16th, 2021
- Improve Libido, Strength, and More with Sermorelin Acetate! - October 6th, 2021
- Ipamorelin Acetate Peptide Treatment Improves HGH Levels - September 10th, 2021
- Melt Stubborn Belly Fat and Restore HGH with Tesamorelin - September 9th, 2021
- Adjusting Lifestyle to Lose Weight in a Way that Improves Hormone Balance - September 6th, 2021
- Major Report Signals Dangers of Microplastics as Endocrine-Disrupting Chemicals - September 6th, 2021
- Comprehensive Blood Panel for Women Interested in Hormone Replacement Therapy - September 6th, 2021
- Preserving Fertility While Treating Testosterone Deficiency - September 6th, 2021
- Norditropin HGH Therapy for Growth Hormone Deficiency - September 6th, 2021
- Menopause HRT Treatment May Protect Women Against Covid-19 - September 5th, 2021
- Vitamins, Nutrients, and Supplements for Healthy Nails, Skin, and Hair - August 6th, 2021
- How Do Hormonal Imbalances Affect Men? - July 20th, 2021
- Dioxins: A Serious Endocrine-Disruptor that Harms Hormone Balance - June 30th, 2021
- Andropause - Protecting Yourself from the Effects of Male Menopause - June 22nd, 2021
- Sleeping Well to Boost HGH and Enhance Hormone Balance - June 3rd, 2021
- Omnitrope HGH Treatments for Growth Hormone Deficiency - May 30th, 2021
- Nevada Sermorelin Prescriptions for HGH Deficiency - May 28th, 2021
- Keto Diet Shows Promise Helping Overweight Guys Boost Testosterone - May 27th, 2021
- The Tom Kerridge Dopamine Diet Can Carry You to a New World of Weight Loss and Pleasure - May 22nd, 2021
- Darkness is Important for Deep Sleep and Hormone Balance - May 20th, 2021
- Will COVID-19 Affect My Testosterone Levels? - May 19th, 2021
- Intermittent Fasting – Enhance Hormone Balance and Live Healthier with a Strategic Diet - May 13th, 2021
- Five Exciting Breakthroughs in Life Extension Medicine - May 6th, 2021
- Nebraska Sermorelin Prescriptions for HGH Deficiency - May 1st, 2021
- Georgia Sermorelin Prescriptions for HGH Deficiency - April 24th, 2021
- Maine Sermorelin Prescriptions for HGH Deficiency - April 23rd, 2021
- Connecticut Sermorelin Clinic for HGH Deficiency Symptoms - April 21st, 2021
- Low Fat Diets Suppress Natural Testosterone Production - April 21st, 2021
- Texas Sermorelin Prescriptions for HGH Deficiency - April 15th, 2021
- West Virginia Sermorelin for HGH Deficiency - April 13th, 2021
- Utah Sermorelin Injections for HGH Deficiency - April 12th, 2021
- New Treatment Shows Promise to Reverse Male-Pattern Baldness - March 23rd, 2021
- Kentucky Sermorelin for HGH Deficiency - March 15th, 2021
- Louisiana Sermorelin Prescriptions for HGH Deficiency - March 12th, 2021
- Oklahoma Sermorelin for HGH Deficiency - March 11th, 2021
- Five Simple Ways to Naturally Increase HGH Levels - March 10th, 2021
- How to Boost HGH Levels Naturally This Year or Supplement with HGH Injections - March 9th, 2021
- South Dakota Sermorelin Injections for HGH Deficiency - March 7th, 2021
- Wyoming Sermorelin Prescriptions for HGH Deficiency - March 6th, 2021
- Illinois Sermorelin Prescriptions for HGH Deficiency - March 5th, 2021
- Maryland Sermorelin for HGH Deficiency - March 3rd, 2021
- Virginia Sermorelin Prescriptions for HGH Deficiency - March 1st, 2021
- Improve Cardiovascular Endurance with Exercise-Based Cardiac Rehabilitation - February 27th, 2021
- Arkansas Sermorelin for HGH Deficiency - February 26th, 2021
- Oregon Sermorelin for HGH Deficiency - February 25th, 2021
- Pennsylvania Sermorelin Prescriptions for HGH Deficiency - February 24th, 2021
- Florida Sermorelin Clinics, Doctors and Injectable Treatment for HGH Deficiency - February 23rd, 2021
- California Sermorelin Clinic, Doctor, Prescriptions for HGH Deficiency - February 22nd, 2021
- Indiana Sermorelin for HGH Deficiency - February 21st, 2021
- Washington Sermorelin Prescriptions for HGH Deficiency - February 20th, 2021
- Idaho Sermorelin Injections for HGH Deficiency - February 19th, 2021
- Delaware Sermorelin for HGH Deficiency - February 17th, 2021
- Elevated Homocysteine Levels May Heighten Risk Of Heart Attack, Stroke, & Alzheimer's Disease - February 16th, 2021
- Missouri Sermorelin Prescriptions for HGH Deficiency - February 15th, 2021
- Colorado Sermorelin Prescriptions for HGH Deficiency - February 15th, 2021
- Kansas Sermorelin Prescriptions for HGH Deficiency - February 12th, 2021
- New Hampshire Sermorelin Injections for HGH Deficiency - February 11th, 2021
- San Francisco Sermorelin Prescriptions for HGH Deficiency - February 9th, 2021
- Understanding Vaginal Dryness, Vaginitis, and Vaginal Atrophy - February 8th, 2021
- Washington, D.C. Sermorelin for HGH Deficiency - February 7th, 2021
Word Count: 1049