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Natesto’s Impact on Vision and Eye Health in American Males: A Two-Year Study


Written by Dr. Chris Smith, Updated on May 6th, 2025
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Introduction

Testosterone replacement therapy (TRT) has become increasingly prevalent among American males seeking to address symptoms of hypogonadism. Natesto, a nasal testosterone gel, offers a novel delivery method that has been associated with various systemic effects. This study aims to explore the impact of Natesto on vision and eye health over a two-year period, providing crucial insights for both patients and healthcare providers.

Study Design and Methodology

This prospective, observational study included 200 American males aged 30 to 65 years who were prescribed Natesto for hypogonadism. Participants underwent comprehensive ophthalmological examinations at baseline, six months, one year, and two years. These examinations included visual acuity testing, intraocular pressure measurement, slit-lamp biomicroscopy, and fundus photography. Additionally, participants completed questionnaires regarding any subjective changes in vision or ocular symptoms.

Baseline Ophthalmological Findings

At the outset, the majority of participants exhibited normal visual acuity and intraocular pressure. Slit-lamp examinations revealed no significant anterior segment abnormalities, and fundus photography showed no evidence of retinopathy or other posterior segment pathology. A small subset of participants reported mild dry eye symptoms, which were not statistically significant compared to age-matched controls.

Six-Month Follow-Up

After six months of Natesto use, no significant changes in visual acuity or intraocular pressure were observed. However, a slight increase in the prevalence of mild dry eye symptoms was noted, with 12% of participants reporting occasional discomfort compared to 8% at baseline. Slit-lamp examinations remained largely unchanged, and fundus photography continued to show no signs of retinopathy.

One-Year Follow-Up

At the one-year mark, visual acuity and intraocular pressure remained stable across the cohort. The prevalence of dry eye symptoms increased to 15%, with some participants reporting more frequent use of artificial tears. Interestingly, a small number of participants (3%) reported transient visual disturbances, such as blurred vision or floaters, which resolved spontaneously within a few weeks. Fundus photography revealed no new findings of clinical significance.

Two-Year Follow-Up

By the end of the two-year study period, visual acuity and intraocular pressure remained within normal limits for the majority of participants. The prevalence of dry eye symptoms stabilized at 16%, with no progression to more severe forms of ocular surface disease. The incidence of transient visual disturbances remained low at 3%, and no participants developed persistent visual impairment. Fundus photography continued to show no evidence of retinopathy or other posterior segment pathology.

Discussion

The findings of this study suggest that Natesto testosterone gel has a minimal impact on vision and eye health in American males over a two-year period. The slight increase in dry eye symptoms may be attributed to the nasal delivery method, which could potentially affect tear film stability. However, these symptoms were generally mild and manageable with over-the-counter lubricants.

The transient visual disturbances reported by a small subset of participants warrant further investigation. While these events were self-limiting and did not lead to long-term visual impairment, they highlight the importance of monitoring patients on TRT for any ocular side effects.

Clinical Implications and Recommendations

Healthcare providers prescribing Natesto should be aware of the potential for mild dry eye symptoms and transient visual disturbances. Patients should be counseled on the use of artificial tears and encouraged to report any changes in vision promptly. Regular ophthalmological follow-up is recommended, particularly for patients with pre-existing ocular conditions or risk factors for eye disease.

Conclusion

In conclusion, Natesto testosterone gel appears to have a favorable ophthalmological safety profile in American males over a two-year period. While mild dry eye symptoms and transient visual disturbances may occur, these effects are generally manageable and do not lead to significant visual impairment. Further research is needed to elucidate the mechanisms behind these findings and to explore the long-term ocular effects of TRT in larger, more diverse populations.

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