Sermorelin: An Enhanced Approach to Addressing Adult-Onset Growth Hormone Insufficiency?

Written by Brianna Clark, Updated on October 17th, 2023
Reading Time: 4 minutes

Adult-onset growth hormone deficiency (AGHD) refers to a lack of GH synthesis in adults, which can lead to a variety of health issues. Sermorelin, a synthetic counterpart of growth hormone-releasing hormone (GHRH), has emerged as a novel treatment option for AGHD. This paper investigates Peptide Sermorelin’s mechanisms of action and pharmacokinetics, assesses clinical studies assessing its efficacy and safety, and speculates on its potential application in treating adult AGHD. It also provides a comprehensive overview of AGHD.


Insufficient GH secretion in adults is a feature of the disease known as adult-onset growth hormone deficiency (AGHD). Although the role of GH in infant growth is well known, it also affects adult metabolism, muscular mass, bone density, and general quality of life. 

Recombinant human growth hormone (rhGH) is widely used as the primary hormone replacement therapy for AGHD. However, there are several disadvantages to rhGH therapy, including the high cost, potential side effects, and the need for frequent Sermorelin injections. Sermorelin, a GHRH substitute, offers an alternative strategy for enhancing endogenous GH secretion. Your body's inside will gain from the Sermorein injections as well. Increasing libido, energy levels, and overall well-being are common experiences for people. They see that they are growing lean muscle mass, decreasing body fat, and becoming stronger. Additionally, strengthening your connective tissues and joints can benefit you. People also observe that their immune systems are working better and that their physical performance has improved.

The purpose of this research is to present an in-depth analysis of Sermorelin as an improved strategy for treating AGHD.

Adult-Onset Growth Hormone Insufficiency:

Two separate clinical conditions can be associated with adult-onset growth hormone deficit (AGHD):

  • Transitioning to adulthood in children with growth hormone (GH) deficit or
  • Adult-onset GH insufficiency (structural/trauma or idiopathic)

The acknowledgment of early mortality linked to hypopituitarism has grown during the past ten years. The standardized death rate is two to three times higher in these hypopituitarian individuals. Macrovascular disease (cardiovascular and cerebrovascular) is most likely to blame for the rise in mortality. Some specialists hypothesized that GHD may have contributed to the higher mortality because these individuals with increased mortality were replaced with steroids and thyroxine, and the majority were on male hormone replacement.

The most common causes of AGHD, accounting for 65% of patients, were pituitary adenoma and craniopharyngioma, according to the KIMS database, a global pharmaco-epidemiological surveillance database for adult hypopituitary patients taking growth hormone treatment. The HypoCCS research showed a beautiful variety of potential GHD etiologies with variations in presenting symptoms during the mid-1990s and mid-2000s. Pituitary adenoma (50.2%), idiopathic growth hormone deficiency (13.9%), craniopharyngioma (13.3%), non-pituitary intracranial tumors (8.2%), non-common diagnosis (7.4%), pituitary hemorrhage (5.8%), and unspecified diagnosis (1.3%) were reported as common causes in the mid-1990s.

By the middle of the 2000s, the same authors found a decline in other reasons such as pituitary adenoma (38%), craniopharyngioma (8.4%), and pituitary hemorrhage (2.8%), along with a rise in idiopathic growth hormone insufficiency (19.3%), non-common causes (15.8%), and unknown causes (8.6%). [1]

Peptide Sermorelin: Mechanism of Action and Pharmacokinetics

Sermorelin has a short half-life of around 7 to 20 minutes and is injected subcutaneously. Its quick elimination from the body lessens the possibility of excessive GH release and lowers the possibility of long-term negative effects. Age-related growth hormone insufficiency can be treated with sermorelin acetate. Every night before bed, inject 0.2 to 0.3 mcg of the synthetic hormone, which is the recommended dosage of Sermorelin.

The shortest synthetic peptide with complete biological action of human growth hormone-releasing hormone (GHRH) is sermorelin, a 29 amino acid equivalent. Growth hormone release from the anterior pituitary is selectively stimulated by intravenous and subcutaneous sermorelin. For the diagnosis of growth hormone insufficiency, hormone responses to intravenous sermorelin 1 microg/kg bodyweight appear to be a quick and relatively specific test. Sermorelin is less likely than other provocative tests to produce false-positive growth hormone responses in children who do not have a growth hormone deficit. In children with growth hormone deficit, the combination of intravenous sermorelin and arginine appears to be a more accurate test, according to adult evidence.

However, subnormal growth hormone responses to additional provocative tests are required to prove the existence of illness in these individuals. Normal growth hormone responses to intravenous sermorelin cannot rule out growth hormone shortage caused by a hypothalamic deficit. In certain prepubescent children with idiopathic growth hormone insufficiency, limited evidence suggests that once-daily subcutaneous sermorelin 30 microg/kg bodyweight administered at sleep is beneficial. Sermorelin therapy for 12 months resulted in significant increases in height velocity and results from a few children indicate that the impact lasts for 36 months. In most children with growth hormone deficiency, sermorelin generated catch-up growth. Children who develop slowly, are shorter, and have delayed bone and height ages seem to respond well to Sermorelin therapy. [2]

The effects of aging may be quite damaging to the skin. The skin may seem wrinkled or drooping when its suppleness declines. Sermorelin treatment can assist aged skin in regaining its youthful condition and look. It has been noticed that this kind of treatment enables the skin to retain more water, giving the skin a fuller, firmer appearance. When the skin is tighter, wrinkles will be less prominent.

Lower resting metabolism results from growth hormone deficit, although sermorelin peptide treatment boosts the metabolism and reverses this condition. This treatment improves protein synthesis, raises fat oxidation, lowers LDL or bad cholesterol, and restores normal glucose metabolism. As a result, these impacts enhance heart health and body composition.


The FDA has given peptide sermorelin acetate approval for the treatment of children, but doctors can also use it to treat growth hormone insufficiency in adults. Adult-onset growth hormone insufficiency is a disorder that can have a major negative influence on a person's quality of life.

A unique and promising method to encourage endogenous GH secretion and treat the symptoms of AGHD is provided by sermorelin, a synthetic analog of GHRH. Its effectiveness and safety have been proven in clinical investigations, adding value to the treatment alternatives for managing AGHD. Sermorelin may become a cornerstone in the treatment of AGHD as research advances, offering a more affordable and physiologically sound substitute for conventional rhGH therapy.

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