Sermorelin Dosage Administration Questions

Written by Dr. Chris Smith, Updated on December 3rd, 2018
Sermorelin Dosage Administration Questions
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Below are the most common questions about using Sermorelin acetate injections that are associated with dosage and administration, we present the "who, what, when, where, how and why." If you don't see the question or topic you are interested in learning about right away, just scroll down and read further. This lengthy article will answer many concerns about usage, dosing, doses, and dosage. If after exploring this article thoroughly you don't see your question here, then please use the contact form to let us know what we should add to this research article.

  • Is it OK to do Sermorelin during the day?

Yes, it is ok to do Sermorelin injections during the day, but generally, the best time to do them is during the late evening before bedtime and with a tinge of stomach hunger.

If you do Sermorelin shots during the day, make sure you haven't eaten 2 hours beforehand, as it might interfere with the hormones functionality regarding the outcome regarding HGH and IGF-1.

Carbs and simple sugar are not the friends of this hormone if they increase your insulin levels dramatically, mainly if the foods cause your glucose levels to spike for more extended periods than usual.

Avoid high glycemic items before injecting hormones like HGH or Sermorelin. If you're not sure what high glycemic items are we will publish research about it on our website for your edification.

But why night versus day?

Think of it this way, the highest amount of human growth hormone release occurs while you're sleeping. The peak release of HGH usually happens between the 7th and 8th hour of deep REM sleep (presuming you are going to sleep on what is considered to be atypical, this spike release is just before dawn).

When you are sleeping this is usually when human body regeneration occurs at its highest peak during the day cycle, therefore doing your injections before you go to your bed will give your body the best opportunity to heal and repair itself while you rest.

Concerning doing Sermorelin shots outside the sleep stage of your daily cycle:

Some patients have found that doing injections during the day on an empty stomach before working out gave them the best results concerning muscle building and fat burning. Some patients who are trying to lose weight have reported a similar feature.

So these (late evening/daytime) are two different circumstances that patients have reported about getting the best results with Sermorelin injections during the 24 hour day period (during the day, or before you go to sleep).

The best thing for you to do is experiment with it and find out what works best for you, but no matter what experimentation you do concerning timing, make sure you are well hydrated with water and haven't eaten in the last 2 hours before doing the shots. Also, consult with your physicians about the different ideas associated with doing sermorelin injections during the day or before sleep.

Why is body hydration so important when doing your daily Sermorelin dose?

Because your body will need more water than normal while using these injections, most people don't hydrate themselves with water.

If you decide to do your shots at night, go to sleep well hydrated, which means take a nice long rinse in the shower (doesn't require that you lather up with soap or wash your hair) and make sure you are adequately hydrated with copious amounts of drinking water.

Even if this means you risk having to get up in the middle of the night to use the restroom, make sure you drink a tall glass of water before bedtime. It is better to go to sleep slightly over-hydrated than risk being dehydrated by the morning.

Hydration while using HRT especially matters in the winter months when the air is cold and dry or summer months when the air conditioner is humming on and stripping the air of moisture.

Whether summer climate control or winter chill, the cold rapidly removes water from your body. Moreover, if you don't want to get out of bed in the middle of the night to urinate, put an empty, and sizeable container that is ideal for a makeshift "bedpan".

Give it some thought as to what works best for you in terms of pee physics and given the fact you don't want any accidental spillage during or when done (non-leakable sealable cover for completion).

Make sure to cover the container tightly before passing out again. Whatever it takes to make sure you are hydrated during the evening. During the day drink more water.

This can not be stated enough and must be repeated over and over: Why is hydration so important because your body will require and utilize a higher quantity of water while using Sermorelin than in your normal state without it. Most people are generally not getting enough water anyway.

  • What is the correct dosage of Sermorelin?

This will depend on many factors, the most important being your weight and IGF-1 levels. This is not an exact science per se, there are dosage recommendations that are usually anywhere from 100 mcg to 500 mcg depending, but it is going to take some finesse and experimentation to get the dose amount correct.

If you are diagnosed with Growth Hormone Deficiency, the way you will ultimately optimize your injection quantity is to start at a low dose in the 100 mcg to 200 mcg range, per night or day, and on an empty stomach.

The cycle you will continue to do while administering these doses is in a daily protocol for around 4 to 6 weeks. Some physicians calculate injections by IU or International Units instead of mcg.

The way you figure IU is to multiply the mg of the vial by 3, so if the bottle of Sermorelin is 2mg, you multiply it by 3, and you get 6 IU. Physicians typically prescribe doses of around half an IU and higher.

What are the lifestyle modifications I should make when doing a Sermorelin injection protocol?

During this 28 to42 day period, you will remove all food-vice from your lifestyle strategy, and you have to keep your caloric intake steady per day, with no wild swings or eating binges.

High nutrient-dense food, supplements and HCG injections can help you curb hunger pangs. Then you will keep a diary of your daily weight, weekly body fat percentage and focus on muscle development through a consistent discipline of 40 minutes of intense cardiovascular exercise three or four times a week on a cross-country or elliptical machine.

On opposing days you will train with weights, giving breaks to different muscle groups.

Finally, you will measure your IGF-1 levels, and the goal will be to increment your dosage so that you reach the IGF-1 levels that range in the 230 to 270 nanogram per deciliter range.

Remember that the higher your IGF-1 range from sermorelin usage, the more likely your risk of HGH side effects occurring. Your goal is to keep your sermorelin dosage maintained so that your IGF-1 levels are leveled off at roughly 250 ng/dl, and this will depend on a lot of different factors, so this is not an exact number.

  • Can I use Sermorelin for Body Building?

Yes, you can use Sermorelin for bodybuilding and muscle development, but it is not indicated for these reasons and therefore is not recommended.

Bodybuilders do Sermorelin doses in the 400 micrograms to 500 micrograms range, which is very high and there is a risk of side effects associated with elevated HGH levels.

Bodybuilders aim to get their IGF-1 levels in the 300 ng/dl to 350 ng/dl range, which will almost inevitably lead to HGH side effects if maintained for an extended period.

You don't often hear bodybuilders talking about Sermorelin injections as often as HGH. Regarding IUs bodybuilders are usually using a dosage of 2 IU to 3 IU, these are outrageously big doses, and long-term usage will almost certainly lead to dangerous side effects.

To calculate the IU of a sermorelin vial, multiply the mg x 3. Thus a 3mg vial of Sermorelin has 9IU when reconstituted with bacteriostatic water. A 2mg vial of Sermorelin has 6 IU when reconstituted with bacteriostatic water.

  • What is the optimal range for IGF-1?

Using Sermorelin for bodybuilding or professional sports is illegal. So keep in mind that you are not using Sermorelin for bodybuilding, but to optimize and balance deficient hormones.

And because the cost is reasonable, you don't have to break the bank to reach this 40 ng/dl span described above (230 ng/dl to 270 ng/dl).

  • What is the price cost to purchase Sermorelin doses?

If I want to buy Sermorelin for this type of dosage protocol what kind of financial commitment would it require to purchase?

The Sermorelin price for a 90-day program cycle is about $900 to $1000 at the middle to high range of cost, or about $10 a day, which is bargain basement price for such a fantastic program that produces such benefits.

The greatest Sermorelin benefits will come from a 180-day plan. You should get your blood re-tested regularly to adjust the dosage. We recommend you start with a three-month Sermorelin cycle before moving up to a six-month period.

  • What does Sermorelin do? How does Sermorelin work?

To answer this question, we should first ask: How does Injectable Sermorelin Therapy Work? Sermorelin does it work? It stimulates the lateral wings of the anterior pituitary gland to release Human Growth Hormone, and the size of the Sermorelin dose will determine the amount HGH released.

Meaning that larger doses of Sermorelin will release more HGH than smaller doses. The reason Sermorelin works this way is that it is a shortened copy of growth hormone-releasing hormone (GHRH), it mostly works in the same way.

  • What is Sermorelin Acetate Therapy?

They discovered in medical laboratories that you can reduce the 44 amino acid of GHRH (the secretagogue released by the hypothalamus) down to 29 amino acids to get the same releasing effect of HGH from the pituitary gland.

Sermorelin was formerly called Geref or GRF 1-29 NH 2, which stands for Growth Hormone Releasing Factor with the numeric information indicating the amino acid chain that is responsible for the effect of the Sermorelin.

Some people believe that sermorelin has anti-aging properties, but actually what you are doing with it is balancing your hormones so that your body functions properly. You can't reverse the age of your cells, but you can experience what it is like to live optimally when a deficiency is present.

This is one of the reasons why many people consider Sermorelin an anti-aging miracle because of the way it gives the appearance and feeling of being younger in most patients who use it correctly under physician supervision.

Most people who use HGH are changing to Sermorelin because it seems to work better in some cases in a more natural manner.

  • How Long Does Sermorelin Take to Work?

Give yourself 3 to 6 months before you get the full effects of Sermorelin therapy.

  • What if I miss a dose of Sermorelin?

Do not double the dose of Sermorelin if you miss a day to catch-up. If you miss a dose, there is nothing to worry about.

Just continue to follow your normal protocol the next day. Missing a dose is not the end of the world, but thinking you should double up because you forgot to do your injection yesterday is a horrible idea, so don't do it.

Doing high doses of Sermorelin can be risky for your health.

  • What is the Sermorelin acetate dosing protocol?

Most Sermorelin protocols follow a five day a week strategy. Some physicians prescribe a seven day a week protocol strategy. These are two different strategies, with the one you give yourself a two day a week break, the other you do the injections daily Monday through Sunday.

Whether you do the doses during the day or evening is already discussed in detail at the beginning of this article.

Regarding Sermorelin cycle length, three months minimum and six months generally speaking to experience the full benefits of injections.

Some people like to take a three month hiatus from the program after only three or six months, but the good thing about hormone replenishment therapy is that you can continue to utilize it as long as your blood work is updated frequently, and you follow-up review with a physical exam and discuss with your doctor any possible Sermorelin benefits, progress or side effects.

  • What is the Sermorelin dosage for weight loss?

Sermorelin dosage for weight loss: One of the things Sermorelin is used for off-label is losing weight. The dosage should aim to get your IGF-1 levels to the 270 ng/dl range, which may require injection doses in the 200 to 400 mcg range, depending on your height, weight, age and HGH levels.

The worst possible thing you can do when you inject hormones is think you can sit back idly and do nothing. You have to exercise daily with Sermorelin to lose weight, and most importantly you have to eat six small meals a day that have a low glycemic index.

The Sermorelin reviews for weight loss have been very promising indeed. Sermorelin for weight management is generally excellent.

  • Does Sermorelin sublingual, pills or sprays work?

Sermorelin sublingual, pills and sprays are trendy hoaxes; injectable sermorelin is what works appropriately, not these other administration versions.

  • How can I prevent Sermorelin Therapy Side Effects?

To avoid sermorelin side effects keep the dosage low enough so that your IGF-1 levels never go above the high 200 ng/dl range, meaning avoid allowing yourself to go above roughly 290 ng/dl.

Sermorelin gets its best reviews for people who keep their IGF-1 scores in the 235 to 255 ng/dl range. For people looking to lose weight, the dosage should be aimed at the 270 ng/dl range.

You also shouldn't use Sermorelin if you have a risk of cancer or have had this disease in the past. What is the safe dosage for sermorelin? When you discover your IGF-1 levels are low, start with small doses like 100 mcg and work your way up and see how you feel.

With Sermorelin sometimes less is more. Never conduct HRT without physician guidance. Sermorelin effectiveness will depend on how well you follow guidelines and avoid abusing it.

  • Can I use Sermorelin to increase my height?

If your epiphyseal plates haven't closed yet, Sermorelin can help you grow taller. Usually, the epiphyseal plates close when a male or female reaches the age of 18 to 19, though this can vary.

Sermorelin is effectively used for children who are short of stature, but once you become an adult, it is not possible to grow taller.

Thoughts on Human Longevity and Hormone Replacement Therapy

Some folks feel that they are automatically going to live a longer life than their parents, and as research in medicine continues to advance with such a swift pace, this belief in rising human longevity is not an unreasonable extrapolation or conclusion.

Every year breakthroughs occur in genetic medicine and stem-cell therapy. Almost every month there are small incremental advancements in biotechnology and nanotechnology.

It is pretty normal in this day and age that Americans are searching for the most natural and most beneficial way to feel and live healthier, and seeking information that will help them to maintain a life that is incredibly productive into their golden years.

Sermorelin Antiaging Therapy


Sermorelin acetate has been shown to be one of the most harmless strategies in the quickly growing genres of youth-revitalizing remedies. The main goal of

Sermorelin anti-aging therapy

is to stimulate the pituitary gland to raise that amount of HGH that is produced in the human body to the levels they were when you were 29 years old. By doing this, it gives you the appearance of reversing some visceral effects of aging that are often harmful accumulations for adults.

We can all look in the mirror and see what aging does to the human body. Through this action of increasing HGH levels, the metabolism gets a significant boost, and stem cells inside the bone marrow get stimulated, letting new cells generate in the organs, as well as the bones.

This burgeoning growth of new tissue is the key to the improvement of one's quality of life if your quality of life might be slipping because your body is not regenerating enough new cells.

HGH and Childhood

During the age range of childhood, especially during puberty, the pituitary gland of the body produces a large quantity of GHRH and these molecules are sufficiently able to cause thereby a young person's body to be awash with HGH via the pituitary gland, and allowing him or her to maintain a high level of health, vitality, and energy, in addition to just being able to efficiently to undergo and sustain the various daily aspects of metabolic function and repair.

  • When do we start noticing Growth Hormone Deficiency?

In many instances, GHRH doesn't function properly regarding how much or when it is released. It fails to produce the needed signal as it, in theory, should (see the HGH decline charts).

When such a thing occurs, aging begins earlier than normal, to the detriment of our bodies. As a person becomes older, declination of GHRH release causes HGH to be created at a level that is much less than optimal for proper metabolic function.

For this reason, it significantly raises the potential for other hormone deficiencies which lead to the erosion of otherwise good health, stamina, and vitality.

Sermorelin FDA

Therapy with Sermorelin acetate is approved by the Food and Drug Administration to treat both young children with short stature, in addition to being considered incredibly safe to use in adults that have a deficiency of Human Growth Hormone.

The Food and Drug Administration (FDA) also has approved treatment with Sermorelin for older people who are going through hormone decline that has resulted in adult-onset growth hormone deficiency diagnosis. Adult Growth Hormone Deficiency (AGHD) is defined when IGF-1 is below 160 ug/ml.

Moreover, doses of Sermorelin generally are based on the severity of the problems and the gender of the patient. Also, it is important to note that it is vital that grown-ups who want to use this therapy must first go through blood testing with a physician that is working with a clinic that is authorized to provide Sermorelin therapy.

Let's discuss some of the Sermorelin Benefits!

Since Sermorelin is a precursor to GH Growth Hormone and helps stimulate the production of HGH into the body's bloodstream, one can expect most of the same benefits that one would expect from HGH injections, but more naturally since Sermorelin allows the body to manufacture HGH adequately. This is a crucial point that is often overlooked and something we discuss in great detail in other articles.

The facts have been proven that Sermorelin indeed boosts energy and endurance. Sermorelin helps to eliminate fat from the body through a process known as lipolysis. It reinvigorates the function of the cardiovascular system, leads to more restful non-Rapid Eye Movement sleep of the slow wave variety, boosts the system of immunity, and enhances the mass and cut of lean muscle on the bones.

  • Can Sermorelin help me recover from physical exertion, illness, and injury?

Most importantly Sermorelin therapy decreases the time and rate of recovery after incurring injuries, sickness, physical activity, wounds or surgery. It also assists in letting the bones retain their calcium and minerals, which makes them stronger and helps them to maintain their ideal density.

More benefits of Sermorelin

Sermorelin also may assist in reducing the amount of glucose that is taken in by the liver, significantly elevate the amount of protein synthesized within the muscles; it contributes to homeostasis in biological energy fuel production and assists in the stimulation of growth of the organs. Sermorelin also gives a significant contribution to the maintenance and function of the islets of the pancreas.

Sermorelin treatment therapy boosts the functions of the kidneys, and in the brain, memory is improved as well.

Patients who suffer from blood pressure that is elevated may realize that their levels of blood pressure may decrease to a far more healthy level.

The function of the immune system is also enhanced, and a significant subset of patients that were suffering from balding reported that they experienced regrowth of hair. Too, smoother, firmer skin with fewer wrinkles and libido increase, in addition to improved sexual function, performance and pleasure.

Sermorelin Acetate Therapy Side Effects

A few particular side-effects occur in those taking Sermorelin treatment therapy as well, in addition to some of the benefits mentioned earlier, these may or may not happen as a result of your particular treatment.

In other articles, we go into great detail about the Sermorelin side effects one can expect with prolonged abuse. Below is just a highlight of some issues one might get in the short term after injecting.

These benefits and side-effects often vary in degree, and some results are rarer than others. One of the side-effects that are experienced commonly is pain or swelling around the area of injection. Some of the more significant side-effects include mild itching or relative discomfort when trying to swallow.

If you find that you are developing either of these issues, we strongly recommend that you get in touch with us as you can.

Other side-effects that are worthy of note but far more rare in their occurrence are hyperactivity, dizziness, vomiting, and headaches. If one experiences these side effects, they should also get in touch with their prescribing doctor. It is in your advantage to do this as quickly as you can.

Usually, when folks are undergoing Sermorelin treatment therapy, it is advised that they are supervised very closely by a doctor that is licensed to perform the treatment.

Our clinic uses standard testing of the blood to review and monitor treatment progress after you start going through the hormone treatment program. This treatment is only available through prescription from a physician, do not buy Sermorelin online without a prescription.

You could be buying dangerous and harmful drugs or end up in jail. We offer legal ways for you to get a Sermorelin prescription.

Sermorelin and Skin Appearance

Sermorelin injection therapy can assist in allowing you to maintain a far younger and healthier appearance. The treatment has gained a pretty significant positive reputation as being a restorer of youth, like the mythical fountain of youth. With the help of Sermorelin, you will undoubtedly find yourself feeling and looking better every day.

Sermorelin and HGH Therapy Together

Can Sermorelin and HGH therapy work together? Ask our anti-aging physician about using Sermorelin Acetate and Human Growth Hormone in tandem.

Though Sermorelin will cause the body to produce more HGH, there still might be a slight deficiency in the body if your pituitary gland is not fully functioning. It is rare that physicians will prescribe Sermorelin HGH Therapy.

The good news is that Sermorelin acetate therapy, though still somewhat expensive for some, is far more affordable than HGH therapy, so using both treatments together has the potential to maximize results while being cost-conscious if the HGH doses are kept low.

If the body has trouble producing HGH naturally with the influence of Sermorelin, however, one would need to use HGH Therapy exclusively. If your pituitary gland is working correctly, Sermorelin alone can get the job done, and you don't need to use both of the said hormones together.

Sermorelin is the new HGH

More antiaging physicians are changing their patients from HGH injections to injectable Sermorelin acetate than ever before.



Sermorelin Acetate

Sermorelin: a review of its use in the diagnosis and treatment of children with idiopathic growth hormone deficiency.


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