Sermorelin: Frequently Asked Questions — Sermorelin Facts

Written by Dr. Chris Smith, Updated on September 17th, 2023
Reading Time: 15 minutes

What is Sermorelin?

Sermorelin is a synthetic pharmaceutical compounded drug, a peptide, derived from a mirrored segment of Growth Hormone-Releasing Hormone (GH-RH). GH-RH is the secretagogue hormone produced by the hypothalamus that produces Human Growth Hormone (HGH) via stimulation.

Although a synthetic hormone, sermorelin is structurally identical to a shortened version of GH-RH - 29 of the 44 amino acids.

GH-RH operates as a chemical messenger that signals the pituitary gland's somatroph cells to send more growth hormone to be delivered to the body.

GH-RH is secreted by the hypothalamus gland, and its secretion is thought to decline with age, and this is one theory as to why humans experience HGH decline.

Sermorelin is a shortened version of GHRH

Thus with the knowledge that Sermorelin contains the same 29 of the 44 peptides proteins that are in GH-RH, scientists have proven that sermorelin has the same effect on the body as GH-RH: promoting additional amounts of HGH from the pituitary gland.

Scientists started by copying the 44 peptide chain of GHRH, and then one by one remove a string, going to 43, 42, 41, 40, all the way down to 29 and found that 29 chains were the shortest they could go to get HGH stimulated.

This means that when they reduced GHRH to 28 strings, it no longer had any physiological effect on the human body for stimulating HGH production in the pituitary gland. Pretty amazing stuff!

Why should I consider using Sermorelin Peptide Injections?

Great question, and a simple answer. Growth hormone (GH) is so vital to our overall health, and its natural decline in the human body leads to many harmful health effects (we list many side effects people experience when their GH levels decline).

Human growth hormone is responsible for the explosive growth seen in puberty and during teenage years until young adulthood in our 20s.

Want proof of what Sermorelin can potentially do?

Consider the fact that children who suffer from low levels of growth hormone grow at a much slower rate than average, and fail to attain the size of their peers.

These children are short of stature and are diagnosed with dwarfism - their sexual organs do not always fully develop like their peers.

Drugs that children are often prescribed for ADHD that can cause the same or similar effect as HGH deficiency, causing some boys, for instance, who grow up, reaching adulthood, with underdeveloped penises or micropenis.

When we reach the end of adolescence and are at our final adult height, the epiphyseal plates of our long bones are sealed, and our levels of growth hormone drop, since the body no longer feels the need for HGH to perform its intended function.

This is all, of course, an oversimplification, there is a lot more complexity to the endocrine system then what is discussed, and there are various reasons why HGH is insufficient in humans going through the natural life cycle.

For instance, sometimes, tumors can grow on the pituitary gland that has the effect of causing HGH to be released in doses insufficient.

Tumors on the pituitary gland can also sometimes lead to a heightened amount of HGH produced or released in the body resulting in acromegaly or gigantism, and you have seen such people who are incredibly tall, in the 6'5" and above height, some reaching 7 feet tall.

HGH levels are needed for normal physiological function

But we still require adequate levels of growth hormone to stay at a high level of physical and mental conditioning concerning normal health, as well as keeping our energy levels high and all systems in our bodies functioning at optimum levels.

Thus the ideal is that sweet spot, or Goldilocks zone, of not too much and not too little, but just right.

When levels get too low in our older age, our bodies naturally do not regenerate and recover the way they used to in youth, leading to many harmful side effects that will be discussed in great detail on this website.

And one thing to remember: HGH is not a magic potion of anti-aging, there is a science behind its replenishment, and more (too much) is not always better.

With HGH, the ideal is hormone optimization, getting just enough replenishment to get a kind of "perfect balance," so to speak.

   Some people think more is better with HGH, and taking massive doses is best, but this is categorically false.

There are dangers associated with too much HGH, and ones IGF-1 levels can reflect this fact.

One should never take high doses of HGH as many bodybuilders, and sports pros do. Abuse or over-use of HGH has many risks and dangers (see our numerous discussions elsewhere about the side effects of too many hormones).

There are even some who believe HGH is the fountain of youth, an anti-aging miracle, and magic bullet. They are sadly mistaken. The entire endocrine system and internal workings of the organs are a symphony of sorts.

When we reach full growth, do we still need growth hormone?

 It might seem like a common rhetorical question: Do humans need optimal levels of HGH in the body for best results? Of Course!

The answer is a loud, resounding "YES"! Here's why. When the level of growth hormone secreted by the pituitary gland slows down or declines precipitously, the aging process accelerates…with its parade of debilitating health problems:

  • Increasing muscle weakness and loss of muscle tone and strength - We watched it happen when we reached our physical peak in our late 20s and early thirties, this is when things tend to peak and begin their decline. By 40, our mortality becomes apparent, as inevitable realizations become cognizant. Many people who have desk jobs careers hit their wall in their late 20s and throughout their 30s. They go to a situation where you sit on your butt all day, then they go home tired and sit on the couch, or the computer desk, pecking away or sitting down to eat at home or in a restaurant. The sedentary lifestyle of sitting during work and sitting during play has caused hundreds of millions of people in the West to experience muscle atrophy and gain lots of fat exactly at their core, right on their buttocks, on the hips, thighs, and stomach. Men are starting to develop wide hips and a pear or apple shape, and it's not just woman going through this disaster of obesity and muscle loss.  The sedentary lifestyle isn't just the only epidemic in America. This problem can also arise from hormone decline precipitated by a radically changing society concerning the chemicals used in growing foods, in our rivers and streams, etc. The incident of endocrine disorders is astonishingly high in modern times.

  • Chronic fatigue - Are you tired for no reason at all? Have you noticed out of nowhere in the middle of the day, you feel tired? Do you find yourself needing coffee even though you just had a full night's sleep? Do you notice you don't rest so good during the night, tossing and turning, or waking up in the middle of the night for no reason? People who do not sleep well at night, people who have insomnia, people who find themselves experience mid-day crashes, might have a hormone imbalance or HGH decline of Testosterone deficiency.

  • Ever-annoying joint aches and pains - we don't just lose our flexibility when we age, but our joints wear-out. The cartilage between our bones recedes. Inflammation sets in, and we get all sorts of aches and pains when we move around, or just conduct ourselves on a day to day period. The lower back, ankles, and knees are usually where the beginnings of such pain begin, but in the computer age, such strains are common in the hands, arms, elbows, and shoulders. Quite frankly, we get those aches and pains everywhere as we age.

  • Brain fog and inability to concentrate: It's a fact. As we age, our memory declines, our intellectual capacity can decrease, not always, but some find themselves forgetting words, forgetting things, and being absent-minded. Some patients who have undergone hormone restoration programs have found they regained superior cognitive.

  • The stiffness of muscles and joints, with a maddening loss of flexibility - we lose flexibility as we age, and this is from a lack of stretching, it can lead to pain in the joints and stiffness. One study showed that adults and seniors who regularly stretch or do yoga oriented exercises remain more flexible and live longer. They actually found that flexibility is a marker for longevity, there appears to be a correlation, though correlation doesn't always mean causation.

  • Dry, weathered skin, with wrinkles making an unwanted appearance

  • Increasing difficulty getting to sleep and staying asleep

  • The pounds pile on, resulting in increased layers of disease-producing blubber, especially in areas least desired

  • More frequent colds, influenza, and other afflictions due to a weakened immune system

  • And more…many many more, too numerous to list!

   The scientific reason behind this is simple. At age 20, the pituitary gland's production of growth hormone is approximately 500 micrograms (?g) daily. Unfortunately, a decade later, the level of HGH produced begins to drop at a rate of (on average) one percent per year or ten percent per decade.

   Do the math. By age 80, our levels of human growth hormone have dropped to about ONE-HALF of what they were at age 30!

It's no coincidence that 80-year-old people suffer far more afflictions than younger people…and the lack of HGH is one of the leading causes of this deplorable condition.

   Numerous studies have concluded that by age 80, the pituitary gland pumps out a mere 60g of HGH…or even less.

To fully appreciate the magnitude of this loss, compare that to the standard measurement for low growth hormone levels, which is considered to be 200g. The pituitary gland isn't just slowing down… it goes on strike!

   As mentioned earlier, this "work slowdown" begins around age 30, and gets progressively worse…unless you do something about it. This is why you need to consider the benefits of sermorelin

What are the Benefits of Sermorelin?

   To answer that, let's go back in time. Remember those teenage years, when you could eat just about anything you wanted, then fall into a deep, restorative sleep…and wake up in the morning and still be able to see your abdominal muscles ("abs").

Or have the ability to process information and solve problems with laser-like precision.

Or have enough energy to do what you wanted, when you wanted, with no thoughts of "slowing down to rest" or "taking a breather."

   For all-too-many aging folks, these days are long ago, in the far distant rear-view mirror.

But it doesn't have to be that way. Sermorelin may not be able to take you all the way back to those days, and most people wouldn't want that, even if they could attain it.

But sermorelin can work wonders when it comes to reversing the debilitating conditions listed above. For example, sermorelin replacement therapy can…

  • Awaken your long-slumbering muscles, and surprise you when your strength comes roaring back. This happens in two ways. First, even if you don't exercise, added growth hormone zooms through your body while you sleep, giving your internal organs the energy they need to strengthen your muscles. Second, you will, perhaps for the first time in years, actually feel like working out! This creates a great feedback loop: more stamina = more exercise = more weight loss

  • Skyrocket your energy levels, and stomp out constant fatigue

  • Ease the pains, aches, and creakiness of your joints

  • Zap your brain fog, and make you want to keep your brain active. As an added benefit, this will make fighting the dreaded Alzheimer's Disease much easier, and give you reason and the willpower to do it

  • Move easier, with more fluidity and flexibility

  • Watch your skin regain much of its youthful glow. This is a result of the role growth hormone plays in preserving the intracellular fluid that connects most of the cells throughout the body. This fluid allows our cells to make and share the building blocks of life. By boosting this fluid, sermorelin plays a vital role in the health of the skin. The skin is our first line of defense against the elements and suffers tons of abuse. When the muscles of the face weaken, the result is sagging, lines, and wrinkles. By strengthening the muscles just below the skin of the face, the wrinkles and lines evaporate, due to being stretched out of existence

  • Finally find it easier to fall into a deep, restorative, and uninterrupted sleep

  • Watch the pounds drop, as the fat and inches melt away

  • Get far more benefit from your exercise routine

  • Enjoy the return of your old, optimistic way of life

  • Bask in the security of an "iron-clad" immune system, strengthened by sermorelin

  • Lower cholesterol. Low growth hormone levels can result in a slow metabolism, which causes numerous problems like elevated cholesterol. This can lead to severe health conditions (i.e., heart attack, stroke, cardiovascular disease, etc.), which can be avoided by restoring your HGH levels

  • Give you "bones of steel." Another devastating consequence of aging and accompanying low growth hormone levels is the dreaded disease that afflicts so many older folks: osteoporosis. High growth hormone levels give you the protection you need to ward off this nightmare by promoting calcium retention

  • And, as a result of all of the above benefits, regain your zest for life. Feel better, think better, look better, and BE BETTER!

   All of these changes occur as a result of sermorelin ramping up your pituitary gland's natural ability to blast out more growth hormone.

As mentioned earlier, when the level of human growth hormone drops due to aging, the body suffers immeasurably, in a wide array of weaknesses and illnesses.

Restoring your hormone balance will restore the functioning of your organs to optimum levels, and allow them to begin attacking the adverse conditions resulting from aging.

   Also, sermorelin cranks up the liver's output of Insulin-Like Growth factor One (IGF-1).

This is accomplished by the increase in growth hormone secreted by the pituitary that makes its way to the liver. The liver then produces more IGF-1. Why is this important?

   For the same reasons that are restoring growth hormone levels are essential. IGF-1 is particularly crucial for conditioning since it boosts lean muscle mass and blowtorches fat.

IGF-1 accomplishes this by moving fat from the problem areas of the body (where it loves to accumulate) and breaking down adipose tissue for energy.

This results in added stamina, causes your libido to explode, promotes neurogenesis (the birth of new neurons in the brain, which helps brain function), and speeds up recovery from injury.

   Still, another benefit of sermorelin is the restoration and preservation of the hypothalamic axis (HPA), also known as the limbic-hypothalamic-pituitary-adrenal axis (LHPA axis).

This axis plays a vital role in maintaining the delicate balance between three endocrine glands: the hypothalamus, the pituitary, and the adrenals.

   The relationship between these three glands regulates our reaction to stress and controls many of our body's functions: emotions, energy storage, digestion, and the immune system.

The interaction of these glands is complicated, but to keep it simple, the job of this axis is to keep your hormones at the exact levels needed.

   Similar to a thermostat, not too hot, not too cold. The axis raises the hormone levels to where they perform correctly, then switches them off.

For example, if the hypothalamic axis is not functioning optimally, too much cortisol ("the stress hormone") may be released, resulting in excess stress flooding the body.

Then the adrenal gland is forced to work overtime and may become exhausted. The result is constant fatigue.

   There are countless other examples of the importance of the hypothalamic axis, but the point should be well-taken: its continued smooth operation is so vital to your hormone balance. Sermorelin will protect the axis, and allow it to do its job as intended.

What is the Difference Between Sermorelin and Growth Hormone Replacement Therapy?

   Both sermorelin replacement therapy and human growth hormone replacement therapy work wonders when it comes to restoring youthful levels of HGH in the body. However, at times, the body does not handle HGH as well as sermorelin.

If excessive levels of growth hormone are administered, natural HGH production by the pituitary gland may fall off.

This may result in a period during which the body is unable to produce natural growth hormone levels…possibly for quite some time.

   Also, on rare occasions, growth hormone replacement therapy may result in side effects like arthritis and carpal tunnel syndrome.

And, HGH replacement therapy may cause temporary blood sugar fluctuations due to rapidly rising or quickly lowering IGF-1 levels.

   But these side effects do not occur with sermorelin.

This is due to sermorelin's ability to coax the body into producing more natural growth hormone as a result of sermorelin therapy causing episodic production of human growth hormone. This is precisely the way the pituitary gland secretes the hormone.

   As you can see, as useful as growth hormone replacement therapy is, it may not be the most expeditious method to restore growth hormone levels.

   The only downside to choosing sermorelin over growth hormone is that it takes somewhat longer to see the results of the therapy.

This is due to an injection of HGH pumping high levels of the hormone into the body quickly, and it continues at a faster pace than when the body produces its own growth hormone.

But many feel that the lower risks of side effects are well worth the wait.

Why should I choose sermorelin over HGH Replacement Therapy?

   As mentioned earlier, they both have the proven, demonstrated ability to restore your long-depleted growth hormone to its youthful levels, with all the attending benefits.

But sermorelin has a few advantages:

  • Sermorelin is safer than HGH since the body regulates sermorelin easier than pure human growth hormone. If the level of sermorelin in the body is a bit excessive, the pituitary gland will signal the hypothalamus gland to lower endogenous (having an internal cause or origin) manufacturing of Growth Hormone-Releasing Hormone. Additionally, the hypothalamus gland produces somatostatins (hormones that are widely distributed throughout the body) that will reduce and monitor the amount of sermorelin or GH-RH that can be absorbed by the pituitary

  • Sermorelin produces a far more natural ebb-and-flow of growth hormone production that doesn't occur with pure human growth hormone injections. HGH injection gives the body a massive blast of growth hormone, which then slowly recedes over several hours.

  • By rousing the pituitary gland more naturally, sermorelin stimulates the hypophyseal portal system, a network of blood vessels that connect the front part of the pituitary with the hypothalamus, strengthening this all-important connection and allowing fast communication between these two glands.

  • Finally, off-label use of sermorelin is not in violation of any federal, state, or local laws. HGH Replacement Therapy, while certainly not illegal, has several more restrictions concerning its off-label usage.

Does Sermorelin Need to be Injected?

   Yes. Subcutaneous (under the skin) injection is currently the only method of delivering sermorelin. But this is quick, simple, painless, and has advantages that you will read about below.

Is Sermorelin Safe?

   YES! Sermorelin is injected, not taken orally. The benefit of this is that the liver and kidneys are removed from the equation since they will not be involved in filtering sermorelin; it will be delivered directly to the pituitary gland.

Also, sermorelin injections contain fewer amino acids. This is important because sermorelin is only needed in small amounts to obtain maximum benefits.

   Consequently, there is no reason to flood the body with massive amounts of amino acids, which may strain the already overworked liver and kidneys.

These remarkable organs perform many filtering duties, 24 hours a day, seven days a week, year in, and year out.

The liver and kidneys are all-too-often taken for granted, but if they stop, you stop! They do not need an additional burden, and injectable sermorelin will not add to their workload.

   However, some folks should not undergo sermorelin replacement therapy. If you are pregnant, make sure you discuss this with your physician and get expressed written permission.

This is also true if you are nursing your baby.

   Cancer patients also need to exercise caution, since there exists the possibility, however slim, of excessive growth hormone levels causing cancer to spread.

   Also, if you are using corticosteroids (hydrocortisone, dexamethasone, and prednisone), be aware that these may be affected by sermorelin.

Make sure to get clearance from your doctor. Another caution flag comes out if you are taking levothyroxine for hypothyroidism. Once again, discuss this with your physician.

What About the Cost? Is Sermorelin Expensive?

   More good news: sermorelin therapy is approximately 10-15% cheaper than HGH replacement therapy.

Also, a vial of sermorelin can last as long as 30 days, which is twice as long as growth hormone. Safe, beneficial results at half the cost!

What About the Dosage of Sermorelin?

   We will determine the dosage you need based upon your medical history, a physical exam, your family history, and your blood work.

We will provide continual monitoring while you are undergoing sermorelin replacement therapy, and you will be instructed to keep us informed of any symptoms.

   Sermorelin is most effective if administered before bedtime. This is vital, since growth hormone is naturally released while sleeping, and thus sermorelin is more effective when taken before sleep.

It is advisable not to eat late at night since sleeping on an empty stomach will help the circadian rhythm and allow the body to turn its full attention and resources to repair and regenerate, rather than digestion.

   And, if you miss a dose, don't worry…it's no big deal. Just resume your regular schedule the next night.

There is no proven benefit for doubling-up the dosage to make up the missed dose, so we don't recommend doing it.

Why Should I Choose Your Clinic?

   Another great question and an important one. Our clinic has decades of experience in administering growth hormone replacement therapy.

We specialize in this area and pride ourselves on being on the "cutting-edge" of all new developments and breakthroughs in this exciting field.

   We will protect you from the ever-increasing number of growth hormone scams that seem too good to be true. They look that way for a reason…they are!

   Fake web pages with extravagant promises, dispensing pills, patches, and sprays are a multi-pronged threat to your health, wealth, and possibly your freedom.

Many of these pages are selling impure products, manufactured under filthy, uncontrolled conditions, with virtually no safety measures.

   If that weren't bad enough, these products are worthless, expensive, and possibly illegal. Steer clear of this siren song by joining our team.

   Finally, we don't use a "cookie-cutter" approach to your sermorelin therapy.

You are a unique individual, and we recognize that.

Your comprehensive program will include specific recommendations for nutrition, reducing stress, supplements, and exercise, in addition to your sermorelin regimen.

All of this will be designed for you and only you.

   Don't waste another day. Let's get going…NOW! Call us. 


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