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If you are an American adult over the age of 30, experiencing the ravages of accelerated aging or premature symptoms of aging, contact us today to find out more about hormone decline and how sermorelin injections can help you improve your quality of life, please fill out our contact form and then call us at 1-800-929-2750.

MetroMDs Holistic HGH Therapy Set to Restore Health and Vitality; Residents of California Have an Exciting …

Los Angeles, CA (PRWEB) July 29, 2014

Human Growth Hormone or HGH is one of the vital hormones that regulate various essential functions of the body. The amount of HGH, which the body can naturally produce, tends to decline with progressing age. The gradual fall in the amount of the HGH hormone in the body can disrupt normal functioning of a humans body. Among a list of several changes in the body, some of the evident symptoms of lower HGH levels include body fatigue, lacking in energy, coarsening of the skin/hair/nail textures, etc. In addition to these all, lack of HGH in children can directly influence the regular growth pattern and/or make an adolescent vertically challenged.

All these above pointers and more such indicators were highlighted in a study conducted by MetroMD and the subsequent reports published in January 14, 2014. The report also highlights the factor involving the role of Growth Hormone (HGH) Therapy for men, women and kids. While HGH can boost several bodily functions and render vigor and vitality in men and women, under experts guidance, HGH therapy was found to aid short statured children and restore normal growth pattern (Ref: http://metromd.net/sermorelin-hgh-the-newest-measure-for-treating-children-of-short-stature/). “Children who have deficient HGH levels are best served by Sermorelin (a growth hormone releasing hormone). For parents looking for the most prominent HGH therapy results in their ward can be served by this hormone (therapy) that serves as a best regenerative medicine for individuals experiencing issues pertaining to Growth Deficiency,” says Dr. Alex Martin, Medical Director at MetroMD.

MetroMD, however, also deals in others areas including the goodness of HGH therapy. According to Mr. Devin Stone, Director of Operation, MetroMD, the institute (MetroMD) treats adult men and women who complain of low energy levels, depleted vitality, coarseness of nails, hair and skin texture all in addition to treating young kids and adolescents suffering from stunted growth and lack of agility. The therapy is FDA approved and helps people to feel healthy and energetic.

In 2003, growth hormone therapy was approved in United States for children with idiopathic short stature with a height at or higher than 2.25 standard deviations. Over the period of a decade, many breakthroughs in the line of this treatment has come to fore and specialists like MetroMD a leading name in regenerative medicines and hormone treatment in California have been one of the biggest exponents of the latest in the HGH therapy.

Dr. Alex Martin detailed on the procedure of the therapy by stating that it (the therapy) is administered with a once-a-day injection schedule that can be used for a multitude of benefits, so as to improve the texture of hair, nail, raise energy levels, boost immunity, and improve lean body mass. To determine who can be the right candidate for the aforesaid therapy, patients have to undergo proper body examinations and lab testing. X-rays of bone growth plates of children is one of the determinants of the adequateness of the Sermorelin therapy.

Dr. Devin Stone welcomes everyone in California – and interested in the HGH therapy – to visit one the MetroMD offices in Los Angeles, Hollywood, Beverly Hills and Orange County.

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MetroMDs Holistic HGH Therapy Set to Restore Health and Vitality; Residents of California Have an Exciting …


HGH Peptides for Anti-Aging are Discussed in Great Detail in New Blog on Fitnessedge.net

MIAMI, July 23, 2014 /PRNewswire/ — Fitnessedge.net, a website that is devoted to offering readers the most up-to-date information about various weight loss programs, has just added some new and educational articles on using hGH peptides for anti-aging and hGH replacement therapy. The newly-posted information includes a comparison of peptides vs hGH in terms of its safety, benefits and cost …

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HGH Peptides for Anti-Aging are Discussed in Great Detail in New Blog on Fitnessedge.net


How Can I Get Prescription Sermorelin Acetate Online?

How Can I Get Prescription Sermorelin Acetate Online?

Are you interested in Bio-Identical Hormone Therapy Treatments Online and don’t know where to turn? If you qualify, we can get you the Sermorelin Acetate Treatments you’ve been searching for, as well as other forms of Hormone Treatment, including Human Growth Hormone, Human Chorionic Gonadotropin, and Testosterone.

In many ways, it’s a lot easier to get Hormone Treatments Online rather than doing everything offline. The treatments are usually cheaper, because Online Hormone Pharmacies specialize in treatments like Sermorelin Acetate, so they can provide the treatments for a better price than a brick-and-mortar pharmacy. Also, since these pharmacies are online, they carry more volume and can get you what you need more quickly.

Getting Sermorelin Online is also cheaper because Hormone Pharmacies like our own have affiliates in your area that can provide the necessary in-person evaluation needed for treatment, and with our advanced logistics, we can provide high quality care remotely using the results of your local appointment.

Let’s go a bit further in depth. These are the steps necessary to qualify for Sermorelin Injections Delivered Directly to Your Door.

Step One: Fill Out a Medical History Questionnaire

Before coming to your appointment, you will be required to fill out a simple health and medical self-evaluation. This provides our Prescribing Physician with important information regarding your current health state and any issues that you or your family have experienced in the past that may affect treatment.

Step Two: Meet With Our Affiliate Physician for a Simple Physical

After filling out the questionnaire, we will arrange for you to meet a local physician in your area that is affiliated with our Hormone Clinic that will perform a fairly routine medical examination which will add information in addition to your Medical Questionnaire and provide clinical confirmation of visible symptoms of Hormone Deficiency.

Step Three: Provide a Blood Sample

Perhaps the most important part of your Hormone Doctor’s Appointment will be a blood sample. This blood sample will be shipped securely to LabCorp, a nationally respected Diagnostic Center that will perform what is known as a Comprehensive Hormone Panel on your blood sample, which will provide our Board Certified Hormone Specialists with a wide variety of information related to your hormone and health status which will give them a vivid picture of your hormone balance and will provide them the health data needed to provide a knowledgeable diagnosis that will meet the needs of your unique physiology.

In addition to testing your IGF-1 and HGH Levels, the testing will unlock a number of other secrets about your health locked in your blood, including your cholesterol levels, Testosterone Levels, and Red Blood Cell Count, in addition to four full pages of medical data.

Step Four: HGH Deficiency (Hypopituitarism) Diagnosis

After the blood sample is fully analyzed by LabCorp, they will send the results directly to our Professional Hormone Clinic, and the Hormone Specialist that we have assigned to your case will analyze the results of your blood testing and provide a qualified diagnosis of your current health state.

Your Hormone Physician will discuss the results with you and answer any questions that you have, so that you can be a fully-informed patient.

Step Five: Prescription

After you have received your diagnosis and understand your health state as according to the diagnostic testing performed, your physician will discuss the options available to you as a patient in order to treat your Hormone Deficiency. For most patients with Age-Related Hypopituitarism, also known as Somatopause or more simply as HGH Deficiency, both Sermorelin Acetate and Bio-Identical Human Growth Hormone are valid treatments for your deficiency, and it will be up to your personal preference which course of treatment will be best for you.

Step Six: Contacting Our Pharmacy and the Shipment of Your Sermorelin Acetate

After you have received your prescription for Injectable Sermorelin Acetate, you can visit our online pharmacy and arrange for the product to be shipped to your home or office. We offer highly competitive prices, some of the best you’ll find online, and we will ship your product via FedEx. All you have to do is sign!

Step Seven: Sermorelin Therapy Follow-Up

Of course, as with any form of Hormone Replacement Treatment, it will be necessary to periodically reassess your health condition, both to see how well your body is taking to your Sermorelin HGH Restoration Therapy and whether the dose needs to be adjusted to meet your needs more effectively or mitigate the risk or appearance of side-effects.

Generally, unless you experience side-effects which necessitate meeting with a physician, we will set up a second appointment with one of our affiliates six months after you begin therapy. After that first visit, you’ll require assessment every six months to one year in order to continue therapy and acquire prescription refills.

Buying Sermorelin Acetate Online Is That Easy

With just a single medical appointment and a few phone calls, you can qualify for Human Growth Hormone Restoration with Sermorelin Acetate. At our hormone clinic, we have dedicated ourselves to providing our patients with the best Hormone Replacement Treatment Options available in the United States.

When you call our clinic, know that we are highly trained and experienced, and our staff all share the common goal of helping our patients live longer and healthier lives through the use of quality Hormone Therapy Products, including Sermorelin Acetate. Sermorelin and Bio-Identical HGH are not Anti-Aging Drugs, but for patients with Human Growth Hormone Deficiency, HGH Restoration can improve health and wellness and potentially add years to a patient’s life, as well as enhance quality of life.

In addition to providing Sermorelin Prescriptions, our clinic also offers in-depth nutrition and exercise suggestions and guidelines in order to optimize your therapy. Understand that in order to receive the best results, you need to improve your habits so that your body and mind can take advantage of your body’s new-found hormone balance

If you are interested in Sermorelin Acetate or any other form of Hormone Treatment, such as HCG or Bio-Identical Testosterone, our clinic is just a message or phone call away from providing you first class care!


What Are the Benefits of Injectable Sermorelin Acetate?

What Are the Benefits of Injectable Sermorelin Acetate?

For men and women that suffer from Age-Related Human Growth Hormone Deficiency, also known as Hypopituitarism or Somatopause, Sermorelin Therapy is a fantastic treatment that can help patients improve their health and hormone balance and improve their quality of life. Sermorelin Injections balance HGH Levels by encouraging the human pituitary to produce more Human Growth Hormone on its own, and for patients suffering from clinically low Human Growth Hormone Production resulting from age related deficiency, many hormone doctors feel that Sermorelin is superior to Bio-Identical HGH.

In this article, we will discuss the benefits of Injectable Sermorelin Acetate, and the changes in your body that you can experience via Physician-Monitored Prescription Sermorelin Therapy.

Sermorelin Acetate Improves Metabolism

When we talk about metabolism, we’re talking about the rate at which your body burns energy and performs its normal, daily functions. Men and women with HGH Deficiency experience symptoms because, at the cellular level, their bodies are no longer to keep up with the demands that help a person maintain optimal health.

Sermorelin Injections can increase metabolism, which helps your various systems meet the needs of the body. This leads to benefits in nearly all of your core systems, and it also increases your energy levels and helps you stay in shape.

Sermorelin Therapy Increases the Strength of the Immune System

As our bodies start to slow down, one of the systems that begins to suffer most quickly is the immune system. Our body relies on the immune system to ward off illness and protect our body from the outside influences that make us sick and cause our bodies to function at less than optimal efficiency.

Sermorelin Acetate increases the activity of the cells that protect us from illness, and it also encourages the proper synthesis of the various factors of the immune system, which further bolsters health.

Sermorelin Helps Burn Fat

As general metabolism starts to fade, this means that our body uses less energy from our diet, and those spare calories have to go somewhere. As our bodies slow down, they become more prone to storing energy taken into the body rather than utilizing it, which upsets normal health balance and erodes body composition.

By enhancing metabolism and encouraging increased muscle activity, Sermorelin Therapy directly contributes to enhanced weight loss, even without making changes in one’s diet. Of course, in order to experience the most powerful gains, you’ll need to participate in a nutrition and exercise program, but Sermorelin enhances the body’s ability to take advantage of these healthy changes.

Sermorelin Therapy Preserves Muscle Mass

The muscles benefit heavily from both Human Growth Hormone and Testosterone. Testosterone directly stimulates the muscles to develop larger and more powerful, but HGH and Sermorelin also play a role, enhancing the body’s healing and restorative processes, especially during sleep.

Muscle atrophy is a big part of hormone decline, and Subcutaneous Sermorelin Injections can help mitigate the general atrophy and loss of strength associated with the aging process. With just six months of painless, daily injections, you can protect your body and preserve your muscle tone and mass, while also enhancing the results of anaerobic exercise and other forms of physical activity.

Sermorelin Therapy Improves Sleeping Habits

Are you having trouble sleeping? Do you wake up tired, in spite of a full night’s sleep? Do you suffer from symptoms of insomnia? Human Growth Hormone is intricately involved in the proper balance of the Circadian Rhythm, and if your body isn’t getting enough of the precious HGH that you need, your ability to sleep will suffer as a direct result.

Injectable Sermorelin Acetate for Human Growth Hormone Deficiency helps to correct sleep deficiency, helping you to stay asleep longer and reach the deeper phases of sleep associated with optimal health and human function.

Sermorelin Injections Can Improve Joint Health

Human Growth Hormone is vitally important during puberty for encouraging the growth and lengthening of the bones, but during adulthood, it also encourages the healthy composition of joint cartilage. As men and women grow older, they start to experience joint pain and inflammation as their bodies no longer protect and preserve the cartilage efficiently, especially after a joint injury.

Sermorelin Injections can improve joint health by encouraging the propagation of smooth cartilage which helps the joints work painlessly and effortlessly to provide maximum range of movement.

Injectable Sermorelin Helps Preserve Normal Psychological Balance

Many people with HGH Deficiency suffer from depression, anxiety, and other symptoms, not only as a result of their perception of their declining health, but also as a direct result of changes in brain balance and chemistry which make it harder to find happiness and satisfaction in life.

Patients that use Sermorelin and other forms of HGH Restoration report that Prescription Human Growth Hormone Therapy improves both their quality of life and their self-perception, while also having a positive effect on mood stability. If you are thirty years or older and are starting to suffer from a case of the blues that you just can’t shake, you’d benefit from getting tested for Human Growth Hormone Deficiency.

Sermorelin Therapy Improves Memory and Focus

The brain is a complex and amazing organ. Optimal hormone balance helps to preserve psychological function in a number of ways. It sharpens memory and helps us pay attention more easily. Part of the issue with HGH Deficiency is that fatigue and energy debt prevent the body from providing the resources necessary to sustain peak cognitive function. Our bodies are too busy trying to meet the core needs of the body that it leads to severe exhaustion and fatigue.

Also, there is powerful evidence that HGH and Sermorelin actually have the capacity to encourage neurological health and balance at the cellular level, actually helping our brains form the connections for memory and cognition more efficiently and readily.

Sermorelin HGH Alternative Enhances Libido

Most people think sex drive is all about sex hormones, but Human Growth Hormone is also important as well. When the body gets tired it directs its resources to self-preservation. Unfortunately, sex drive and sexual ability have a tendency to fall by the wayside as the body’s needs change as a direct result of hormone imbalance.

If the spark has left your bedroom in recent months or years, and you are unsure why, a trip to a licensed and board-certified hormone specialist can help you find out if you need Sermorelin Acetate or Testosterone to increase and enhance your love and desire for your partner.

Sermorelin Improves Skin Appearance and Health

Injectable Sermorelin Acetate even improves skin health! Wrinkles and sagging skin are two of the trademark signs of aging. The muscles underneath the skin lose their strength and tone, causing the skin to droop off the bone. Also, intracellular fluid levels in skin cells start to drop, both reducing the fullness of the skin and preventing the cells from transporting resources to one another, further degrading skin health.

With Sermorelin Therapy, you can help strengthen your skin both at the cellular level and and the subdermal level, helping your skin reflect the new and improved you that’s developing inside as a result of Hormone Therapy with Sermorelin.

Ask Yourself: Can I Benefit from Sermorelin Injections?

Aging is an unfortunate and inevitable process, but men and women suffering from Somatopause and Age-Related HGH Deficiency don’t have to surrender themselves to the decline in health and wellness associated with declining Human Growth Hormone Levels.

If you are interested in Sermorelin Acetate, we encourage you to fill out the form on this page, or contact us at the listed number in order to set up an appointment with one of our Board-Certified Hormone Specialists!


Sermorelin Injecting Instructions | andrologix.com – Video



Sermorelin Injecting Instructions | andrologix.com
This video is intended for patients of Andrologix Health Wellness only. If you are not our patient, please consult your own doctor for instructions and gui…

By: Andrologix

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Sermorelin Injecting Instructions | andrologix.com – Video


Sermorelin from Peptide Pros – Video



Sermorelin from Peptide Pros
Peptide Pros has the highest quality Sermorelin, IGF-1 and other peptides available online. www.peptidepros.net.

By: Peptide Pros

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Sermorelin from Peptide Pros – Video


Supplementing Testosterone with HCG

Supplementing Testosterone with HCG

Testosterone Restoration is a fantastic way to treat Low-T. Actually, as of today, it’s the only real and effective way to return Testosterone Levels to normal after Andropause. There are a few issues related to Testosterone that could give you pause, however.

Testosterone Supplementation Suppresses Natural Testosterone Production

For one, Testosterone Therapy reduces the body’s ability to produce its own Testosterone. Now, this isn’t necessarily a bad thing. If you are suffering from Low-T or Andropause, your body is no longer able to produce the amount of Testosterone needed to sustain optimal function, so you need to do something to get your Testosterone Levels back to normal, because no amount of diet or exercise is going to get you above a certain level of Androgen function beyond that which you are limited to by age and genetics.

So, men with Low-T turn to Testosterone Replacement with Gels, Patches, Creams, or Injections, and are able to enhance their health and body composition in a number of beneficial ways, but the natural hormone rhythms of the body do benefit from some level of natural Testosterone Production. So, what can you do?

How Does Testosterone With HCG Sustain Testosterone Production?

If you are interested in preserving your body’s natural rhythms, you may be interested in combining Bio-Identical Human Chorionic Gonadotropin to your Testosterone Therapy. HCG is a natural hormone that is normally only produced by the female body during pregnancy. Interestingly enough, however, this hormone is responsible for some very masculine effects when applied to the male body. HCG is a functional analogue of a hormone produced by both sexes under normal circumstances known as Luteinizing Hormone.

In the female body, Luteinizing Hormone helps regulate the menstrual cycle, but in the male body, Luteinizing Hormone preserves the normal manufacture and secretion of Testosterone by the testes, and it also encourages the testes to produce sperm for fertility. By supplementing your Testosterone Therapy with HCG Injections, it is possible to maintain a baseline level of natural, endogenous Testosterone Production which preserves your physiological ability to produce Testosterone, while Testosterone Treatments raise your Testosterone Levels to their optimal state so that you can experience the benefits of both Prescription Testosterone and Natural Testosterone simultaneously.

Testosterone Therapy Inhibits Fertility

Another issue with Testosterone Optimization for Andropause is that it reduces your fertility. The body has various mechanisms through which it can monitor concentrations of Testosterone in the body, and if the body recognizes that there is an outside source of Testosterone providing the hormone to the body, it will send signals to the hypothalamus to reduce production. The body produces less Luteinizing Hormone and Follicle-Stimulating Hormone in response.

This has minimal effects upon the overall health of the body, because the body is still getting the Testosterone that it needs-it’s actually getting more Testosterone than it was getting before! The main issue with regard to Testosterone Patches, Injections, and Gels is that the body no longer produces the signal for Luteinizing Hormone, which is responsible for the production and proliferation of healthy sperm cells.

As the body becomes accustomed to the influx of Real Bio-Identical Testosterone, it slowly drops its production of Testosterone Precursors, which slowly reduces fertility over time. If a patient uses Testosterone long enough, he will actually eventually become effectively infertile. Luckily, however, this infertility is only a temporary symptom of treatment, and if the patient stops taking Testosterone, fertility can slowly return to pre-treatment levels.

Taking Testosterone with HCG Can Protect Fertility, Even During Treatment

In relationship to its ability to sustain normal production of Testosterone, HCG also simulates Luteinizing Hormone and promotes the normal production of sperm by the testes. In doing so, it preserves fertility.

If you are looking to choose Testosterone Optimization to preserve and foster greater health and protect yourself against some of the most devastating effects of aging and premature aging, but you also want to preserve your fertility potential, the best course of action would be to take Subcutaneous HCG in combination with Testosterone in order to maximize your fertility potential during treatment.

Of course, another option you have available to you if you are not interested in HCG is that you can deposit your sperm at a sperm bank. In doing so, you don’t have to worry about your physiological fertility.

Testosterone Replacement Therapy Can Impact the Size and Appearance of the Testicles

A third issue with Testosterone Treatment is cosmetic. As we mentioned earlier, Bio-Identical Testosterone Restoration limits the productive activity of the reproductive system both in regard to the production of Endogenous Testosterone as well as sperm.

Because the testes become less active over the course of Testosterone Therapy, they actually shrink and recede slightly, and this also causes the testicles to shrink and become less full. If you are interested in looking your best in the bedroom, you may become a bit embarrassed about this. Don’t let this affect your interest in treatment, however!

Testosterone with HCG can Preserve the Aesthetic Appearance of Your Testicles

Because Human Chorionic Gonadtropin preserves a baseline production of Testosterone and Sperm by the Testes, this prevents the physical changes in appearance associated with Testosterone Restoration Treatment. In addition to enhancing your sexual, physical, and psychological health with Testosterone, you are also protecting yourself from changes in appearance associated with treatment!

If You Decide to Take a Break From or Discontinue Therapy, The Body Regains It’s Natural Testosterone Production Slowly

A final major issue with how the human body reacts to Testosterone Therapy is that the body recovers relatively slowly from the end of treatment. If you have been taking Testosterone for six months to a year, your body’s natural production of the hormone is very, very low, and it will take time for it to come back to normal.

HCG Can Be Used in Order to Restore Normal Testosterone Production Quickly After Therapy

If you choose to undergo Testosterone Therapy on its own, your Hormone Prescribing Specialist may recommend that you undergo occasional Testosterone Cycling. This means that you will take Testosterone alone for awhile, and then occasionally, you will take brief breaks from Testosterone in order to keep your on body’s production at a certain capacity. In this case, your physician will prescribe you with HCG during the breaks so that your body will more quickly adapt to the absence of outside Testosterone.

In addition to this, if you ever choose to suspend Testosterone Treatments for an extended period of time, and would like to get your Endogenous Testosterone Production back up to normal more quickly, your Prescribing Hormone Physician can also prescribe you with HCG in order to get your Testosterone Levels back to normal for your Age and Genetics.

Are You Interested in Supplementing Testosterone Therapy with HCG?

If you are interested in Testosterone Creams, Patches, or any other form of Testosterone Optimization, our clinic offers high-quality, Physician-Monitored Hormone Therapy, and if you qualify, we can get you the treatment that you’re looking for, for some of the best prices available in America today. We can also provide you with HCG if you are looking to supplement your therapy.

We are also happy to offer a wide variety of Hormone Replacement Products and Services, including Human Growth Hormone Injections, Injectable Sermorelin Acetate, and HCG Injections for Weight Loss. If you are interested in these or any other form of Hormone Treatment, we encourage you to contact us via the form on this page and fill out the simple medical questionnaire.

We can also take your call at the number above. One of our friendly and knowledgeable Board-Certified Hormone Therapy Specialists will be happy to take your call and answer any questions!

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Supplementing Testosterone with HCG


Sermorelin | Peptide Sciences

Sermorelin Acetate, also known as GRF 1-29, is a Growth Hormone Releasing Hormone (GHRH) produced by the brain that stimulates the production and release of Growth Hormone (GH). Sermorelin Acetate was first developed in the 70s, which is thought to be the shortest fully functional fragment of GHRH and has been used as a test for Growth Hormone secretion. It is often used extensively in Anti-aging Therapy along with Testosterone in men. Sermorelin Acetate affects a more primary source of failure in the GH neuroendocrine axis, has more physiological activity, and its use for adult hormone deficiency is not restricted. Compared to human Growth Hormone (hGH), Sermorelin Acetate is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete growth hormone. Also, Sermorelin Acetate and Modified GRF 1-29 contains 29 amino acids whereas hGH is a larger molecule containing 191 amino acids.

Sequence: H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2 Molecular formula: C149H246N44O42S Molar Mass: 3357.96 CAS number: 86168-78-7 PubChem: CID 16133753 Synonyms: Sermorelin acetate hydrate, GRF 1-29 NH2

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Sermorelin | Peptide Sciences


GHRH – Growth-Hormone Releasing Hormone | Peptidesciences.com

Growth Hormone Releasing Hormone is commonly referred to as GRF (Growth Hormone Releasing Factor) or GHRH 1-44 because it is a peptide of 44 amino acids. Research studies have shown that in most species GRF (1-44) stimulates the release and synthesis of growth hormone. GRF is synthesized by neurons in the arcuate nucleus of the hypothalamus. After being released into the pituitary portal circulation, it stimulates GH release by the somatotrophs in the pituitary gland. Endogenous GHRH (1-44) has a very short active life, but is released from the hypothalamus before traveling a very short distance to the anterior pituitary, where GH is released. In contrast, exogenous peptides are typically supplied exogenously through one of several types of injection, and must circulate prior to reaching the pituitary and activating the GH-storing-and-releasing cells called somatotrophs. Research studies have shown that GHRH helps stimulate the release and synthesis of growth hormone. Research has also shown that It helps promotes slow-wave sleep. GHRH is synthesized by neurons in the arcuate nucleus of the hypothalamus. GHRH stimulates GH production and release by binding to the GHRH Receptor GRFR on cells.

CJC-1295 DAC, a tetrasubstituted analog of GRF 1-29, has a D-Ala at the 2-position, a Gln at the 8-position to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, an Ala at position 15 to enhance bioactivity, and a Leu at position 27 to prevent methionine oxidation along with the MPA-Lys at the C terminus. CJC-1295 is a maleimido derivative of GRF 1-29, which is modified in such a way that it has the ability to bioconjugate with serum albumin, thus increasing its half-life and possible therapeutic window.

Modified GRF 1-29 is a tetrasubstituted analog of GRF 1-29 that has a D-Ala at the 2-position, a Gln at the 8-position to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, an Ala at position 15 to enhance bioactivity, and a Leu at position 27 to prevent methionine oxidation. Mod GRF 1-29 is modified in such a way that increasing its half-life and possible therapeutic window, but in a more natural pulsatile manner similar to GRF 1-44.

Sermorelin is a growth hormone releasing hormone analogue which is a 29-amino acid polypeptide representing the 1-29 fragment from endogenous human growth hormone releasing hormone, and is thought to be the shortest fully functional fragment of GHRH.

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GHRH – Growth-Hormone Releasing Hormone | Peptidesciences.com


Sermorelin Acetate (Sermorelin) Drug Information: Clinical …

Sermorelin acetate for injection increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Sermorelin is similar to the native hormone (GRF [1-44]-NH 2 ) in its ability to stimulate GH secretion in humans. Pharmacokinetics

In subcutaneous administration of 2 mg sermorelin to 12 normal volunteers, peak concentrations of sermorelin were reached in 5-20 minutes. The mean absolute bioavailability after SC administration is about 6%.

After intravenous administration of 0.25-1.0 mg Sermorelin to 12 normal volunteers, the mean volume of distribution ranged between 23.7-25.8 liters.

No metabolism studies have been performed in humans.

Sermorelin is rapidly cleared from the circulation, with clearance values in adults ranging between 2.4-2.8 L/min. The halflife of Sermorelin is short, 11-12 minutes after either intravenous or subcutaneous administration.

Gender/Age: No gender data are available in pediatric patients. In normal adults, the clearance of sermorelin in men and women is similar. No age data are available.

Renal/Hepatic Insufficiency: No data are available.

Last reviewed on RxList: 7/16/2008 This monograph has been modified to include the generic and brand name in many instances.

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Sermorelin Acetate (Sermorelin) Drug Information: Clinical …

Sermorelin Ghrp6

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